Cell Biology Antibodies 18

Anti-ZHX2 Antibody (CAB18235)

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SKU:
CAB18235
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ZHX2 Antibody
Antibody SKU:CAB18235
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ZHX2.
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, 293T, Raji, LO2, Mouse brain
Immunogen:Recombinant protein of human ZHX2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:22882
Uniprot:Q9Y6X8
Cellular Location:
Calculated MW:92kDa
Observed MW:120kDa
Anti-ZHX2 Antibody (CAB18235)Western blot - ZHX2 Polyclonal Antibody (CAB18235)
Synonyms:RAF, AFR1, ZHX2
Background:The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.
UniProt Protein Function:ZHX2: Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. Belongs to the ZHX family.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8q24.13

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function:identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity; transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

NCBI Summary:The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y6X8
NCBI GenInfo Identifier:44888553
NCBI Gene ID:22882
NCBI Accession:Q9Y6X8.1
UniProt Related Accession:Q9Y6X8
Molecular Weight:92,307 Da
NCBI Full Name:Zinc fingers and homeoboxes protein 2
NCBI Synonym Full Names:zinc fingers and homeoboxes 2
NCBI Official Symbol:ZHX2  
NCBI Official Synonym Symbols:RAF; AFR1  
NCBI Protein Information:zinc fingers and homeoboxes protein 2
UniProt Protein Name:Zinc fingers and homeoboxes protein 2
UniProt Synonym Protein Names:Alpha-fetoprotein regulator 1; AFP regulator 1; Regulator of AFP; Zinc finger and homeodomain protein 2
Protein Family:Zinc fingers and homeoboxes protein
UniProt Gene Name:ZHX2  
UniProt Entry Name:ZHX2_HUMAN
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