Cell Biology Antibodies 12
Anti-ZFYVE9 Antibody (CAB9041)
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- SKU:
- CAB9041
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ZFYVE9 Antibody |
| Antibody SKU: | CAB9041 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MENY FQAE AYNL DKVL DEFE QNED ETVS STLL DTKW NKIL DPPS HRLS FNPT LASV NESA VSNE SQPQ LKVF SLAH SAPL TTEE EDHC ANGQ DCNL NPEI ATMW IDEN AVAE DQLI KRNY SWDD QCSA VEVG EKKC GNLA CLPD EKNV LVVA VMHN CDKR TLQN DLQD CNNY NSQS LMDA FSCS LDNE NRQT DQFS FSIN ESTE KDMN SEKQ MDPL NRPK TEGR SVNH LCPT SSDS LASV CSPS QLKD DGSI GRDP SMSA |
| Gene ID: | 9372 |
| Uniprot: | O95405 |
| Cellular Location: | Cytoplasm, Early endosome membrane |
| Calculated MW: | 83kDa/150kDa/156kDa |
| Observed MW: | 156kDa |
| Synonyms: | ZFYVE9, MADHIP, NSP, PPP1R173, SARA, SMADIP |
| Background: | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
| NCBI Summary: | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| UniProt Code: | O95405 |
| NCBI GenInfo Identifier: | 47717106 |
| NCBI Gene ID: | 9372 |
| NCBI Accession: | NP_004790.2 |
| UniProt Secondary Accession: | O95405,Q5T0F6, Q5T0F7, Q9UNE1, Q9Y5R7, |
| UniProt Related Accession: | O95405 |
| Molecular Weight: | 83,721 Da |
| NCBI Full Name: | zinc finger FYVE domain-containing protein 9 isoform 3 |
| NCBI Synonym Full Names: | zinc finger FYVE-type containing 9 |
| NCBI Official Symbol: | ZFYVE9 |
| NCBI Official Synonym Symbols: | NSP; SARA; MADHIP; SMADIP; PPP1R173 |
| NCBI Protein Information: | zinc finger FYVE domain-containing protein 9 |
| UniProt Protein Name: | Zinc finger FYVE domain-containing protein 9 |
| UniProt Synonym Protein Names: | Mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; Novel serine protease; NSP; Receptor activation anchor; hSARA; Smad anchor for receptor activation |
| Protein Family: | Sarafotoxin |
| UniProt Gene Name: | ZFYVE9 |
 | Western blot analysis of extracts of various cell lines, using ZFYVE9 antibody (CAB9041) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunofluorescence analysis of HeLa cells using ZFYVE9 antibody (CAB9041) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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