Cell Biology Antibodies 11
Anti-ZFYVE16 Antibody (CAB7766)
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- SKU:
- CAB7766
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ZFYVE16 Antibody |
| Antibody SKU: | CAB7766 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZFYVE16 (NP_055548.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ZFYVE16 (NP_055548.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MDSY FKAA VSDL DKLL DDFE QNPD EQDY LQDV QNAY DSNH CSVS SELA SSQR TSLL PKDQ ECVN SCAS SETS YGTN ESSL NEKT LKGL TSIQ NEKN VTGL DLLS SVDG GTSD EIQP LYMG RCSK PICD LISD MGNL VHAT NSEE DIKK LLPD DFKS NADS LIGL DLSS VSDT PCVS STDH DSDT VREQ QNDI SSEL QNRE IGGI KELG IKVD TTLS DSYN YSGT ENLK DKKI FNQL ESIV DFNM SSAL TRQS SKMF HAKD KLQH KSQP CGLL KDVG LVKE |
| Gene ID: | 9765 |
| Uniprot: | Q7Z3T8 |
| Cellular Location: | Cytoplasm, Early endosome membrane, Peripheral membrane protein |
| Calculated MW: | 88kDa/168kDa |
| Observed MW: | 100kDa |
| Synonyms: | ZFYVE16, PPP1R69 |
| Background: | This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | endofin: May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 5q14 Cellular Component: cytoplasm; early endosome; early endosome membrane; intracellular membrane-bound organelle Molecular Function:phosphatidylinositol binding; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein transporter activity Biological Process: BMP signaling pathway; endosome transport; protein targeting to lysosome; regulation of endocytosis |
| NCBI Summary: | This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q7Z3T8 |
| NCBI GenInfo Identifier: | 296453075 |
| NCBI Gene ID: | 9765 |
| NCBI Accession: | Q7Z3T8.3 |
| UniProt Secondary Accession: | Q7Z3T8,O15023, Q5H9U2, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3 |
| UniProt Related Accession: | Q7Z3T8 |
| Molecular Weight: | 88,377 Da |
| NCBI Full Name: | Zinc finger FYVE domain-containing protein 16 |
| NCBI Synonym Full Names: | zinc finger FYVE-type containing 16 |
| NCBI Official Symbol: | ZFYVE16 |
| NCBI Official Synonym Symbols: | PPP1R69 |
| NCBI Protein Information: | zinc finger FYVE domain-containing protein 16 |
| UniProt Protein Name: | Zinc finger FYVE domain-containing protein 16 |
| UniProt Synonym Protein Names: | Endofin; Endosome-associated FYVE domain protein |
| Protein Family: | Zinc finger FYVE domain-containing protein |
| UniProt Gene Name: | ZFYVE16 |
| UniProt Entry Name: | ZFY16_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using ZFYVE16 antibody (CAB7766) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using ZFYVE16 antibody (CAB7766) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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