Cell Biology Antibodies 14

Anti-ZFPM1 Antibody (CAB18183)

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SKU:
CAB18183
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ZFPM1 Antibody
Antibody SKU:CAB18183
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human ZFPM1 .
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, Mouse liver, Mouse brain, Rat liver
Immunogen:Recombinant protein of human ZFPM1 .
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:161882
Uniprot:Q8IX07
Cellular Location:
Calculated MW:104kDa
Observed MW:104kDa
Anti-ZFPM1 Antibody (CAB18183)Western blot - ZFPM1 Rabbit pAb (CAB18183)
Synonyms:FOG, FOG1, ZNF408, ZNF89A, ZC2HC11A, ZFPM1
Background:
UniProt Protein Function:FOG1: Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2. Belongs to the FOG (Friend of GATA) family.
UniProt Protein Details:

Protein type:Transcription regulation; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 16q24.2

Cellular Component: nucleoplasm; nucleus; transcription factor complex; transcriptional repressor complex

Molecular Function:protein binding; transcription factor binding

Biological Process: blood coagulation; cardiac muscle morphogensis; embryonic hemopoiesis; erythrocyte differentiation; heart development; megakaryocyte differentiation; negative regulation of fat cell differentiation; negative regulation of interleukin-4 biosynthetic process; negative regulation of protein binding; platelet formation; positive regulation of interferon-gamma biosynthetic process; T-helper cell lineage commitment

UniProt Code:Q8IX07
NCBI GenInfo Identifier:296434508
NCBI Gene ID:161882
NCBI Accession:Q8IX07.2
UniProt Related Accession:Q8IX07
Molecular Weight:104,888 Da
NCBI Full Name:Zinc finger protein ZFPM1
NCBI Synonym Full Names:zinc finger protein, FOG family member 1
NCBI Official Symbol:ZFPM1  
NCBI Official Synonym Symbols:FOG; FOG1; ZNF408; ZNF89A; ZC2HC11A  
NCBI Protein Information:zinc finger protein ZFPM1
UniProt Protein Name:Zinc finger protein ZFPM1
UniProt Synonym Protein Names:Friend of GATA protein 1; FOG-1; Friend of GATA 1; Zinc finger protein 89A; Zinc finger protein multitype 1
Protein Family:Zinc finger protein
UniProt Gene Name:ZFPM1  
UniProt Entry Name:FOG1_HUMAN
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