Signal Transduction Antibodies 1
Anti-ZFAND5 Antibody (CAB13185)
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- SKU:
- CAB13185
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-ZFAND5 Antibody |
| Antibody SKU: | CAB13185 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human ZFAND5 (NP_001095890.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-150 of human ZFAND5 (NP_001095890.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RQQN SGRM SPMG TASG SNSP TSDS ASVQ RADT SLNN CEGA AGST SEKS RNVP VAAL PVTQ QMTE MSIS REDK ITTP KTEV SEPV VTQP SPSV SQPS TSQS EEKA PELP KPK |
| Gene ID: | 7763 |
| Uniprot: | O76080 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
| Synonyms: | ZFAND5, ZA20D2, ZFAND5A, ZNF216 |
| Background: |
| UniProt Protein Function: | Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. |
| UniProt Code: | O76080 |
| NCBI GenInfo Identifier: | 156231047 |
| NCBI Gene ID: | 7763 |
| NCBI Accession: | NP_001095890.1 |
| UniProt Secondary Accession: | O76080,A8K484, |
| UniProt Related Accession: | O76080 |
| Molecular Weight: | 23,132 Da |
| NCBI Full Name: | AN1-type zinc finger protein 5 |
| NCBI Synonym Full Names: | zinc finger AN1-type containing 5 |
| NCBI Official Symbol: | ZFAND5 |
| NCBI Official Synonym Symbols: | ZA20D2; ZNF216; ZFAND5A |
| NCBI Protein Information: | AN1-type zinc finger protein 5 |
| UniProt Protein Name: | AN1-type zinc finger protein 5 |
| UniProt Synonym Protein Names: | Zinc finger A20 domain-containing protein 2; Zinc finger protein 216 |
| Protein Family: | AN1-type zinc finger protein |
| UniProt Gene Name: | ZFAND5 |
 | Western blot analysis of extracts of mouse eye, using ZFAND5 Antibody (CAB13185) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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