Cell Biology Antibodies 7

Anti-ZDHHC8 Antibody (CAB17348)

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SKU:
CAB17348
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ZDHHC8 Antibody
Antibody SKU:CAB17348
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ZDHHC8 (NP_037505.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, K562, mouse heart, mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ZDHHC8 (NP_037505.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VEHV LCSP LAPR YVVE PPRL PLAV SLKP PFLR PELL DRAA PLKV KLSD NGLK AGLG RSKS KGSL DRLD EKPL DLGP PLPP KIEA GTFS SDLQ TPRP GSAE SALS VQRT SPPT PAMY KFRP AFPT GPKV PFCG PGEQ VPGP D
Gene ID:29801
Uniprot:Q9ULC8
Cellular Location:
Calculated MW:81kDa
Observed MW:81kDa
Synonyms:ZDHHC8, DHHC8, ZDHHCL1, ZNF378
Background:This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.
UniProt Protein Function:ZDHHC8: Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transferase; EC 2.3.1.225; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytosol; Golgi apparatus

Molecular Function:palmitoyltransferase activity; protein-cysteine S-palmitoleyltransferase activity

Biological Process: lipoprotein metabolic process; protein palmitoylation

NCBI Summary:This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
UniProt Code:Q9ULC8
NCBI GenInfo Identifier:57015419
NCBI Gene ID:29801
NCBI Accession:Q9ULC8.3
UniProt Secondary Accession:Q9ULC8,Q2TGE9, Q6ICL1, Q6ZNF5, Q7Z6L9,
UniProt Related Accession:Q9ULC8
Molecular Weight:83,173 Da
NCBI Full Name:Probable palmitoyltransferase ZDHHC8
NCBI Synonym Full Names:zinc finger DHHC-type containing 8
NCBI Official Symbol:ZDHHC8  
NCBI Official Synonym Symbols:DHHC8; ZNF378; ZDHHCL1  
NCBI Protein Information:probable palmitoyltransferase ZDHHC8
UniProt Protein Name:Probable palmitoyltransferase ZDHHC8
UniProt Synonym Protein Names:Zinc finger DHHC domain-containing protein 8; DHHC-8; Zinc finger protein 378
Protein Family:Probable palmitoyltransferase
UniProt Gene Name:ZDHHC8  
UniProt Entry Name:ZDHC8_HUMAN
Anti-ZDHHC8 Antibody (CAB17348)Western blot analysis of extracts of various cell lines, using ZDHHC8 antibody (CAB17348) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3min.
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