Cell Biology Antibodies 10
Anti-ZDHHC17 Antibody (CAB6793)
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- SKU:
- CAB6793
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ZDHHC17 Antibody |
| Antibody SKU: | CAB6793 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-310 of human ZDHHC17 (NP_056151.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60, SKOV3, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-310 of human ZDHHC17 (NP_056151.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TSIV AYLI AKGQ DVDM MDQN GMTP LMWA AYRT HSVD PTRL LLTF NVSV NLGD KYHK NTAL HWAV LAGN TTVI SLLL EAGA NVDA QNIK GESA LDLA KQRK NVWM INHL QEAR QAKG YDNP SFLR KLKA DKEF RQKV MLGT P |
| Gene ID: | 23390 |
| Uniprot: | Q8IUH5 |
| Cellular Location: | Cytoplasmic vesicle membrane, Golgi apparatus membrane, Multi-pass membrane protein |
| Calculated MW: | 22kDa/23kDa/72kDa |
| Observed MW: | 68kDa |
| Synonyms: | ZDHHC17, HIP14, HIP3, HSPC294, HYPH |
| Background: |
| UniProt Protein Function: | HIP14: a palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, PSD-95, GAD2, SYT1 and Huntingtin. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Can cause cellular transformation, and is up-regulated in a number of types of human tumors. Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate, and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.3.1.225; Transferase; Membrane protein, multi-pass; Membrane protein, integral; Tumor suppressor Chromosomal Location of Human Ortholog: 12q21.2 Cellular Component: Golgi membrane; Golgi apparatus; intracellular membrane-bound organelle; cytoplasm; integral to membrane Molecular Function:identical protein binding; signal transducer activity; protein binding; zinc ion binding; palmitoyltransferase activity; magnesium ion transmembrane transporter activity; protein-cysteine S-palmitoleyltransferase activity Biological Process: protein palmitoylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipoprotein transport; signal transduction; magnesium ion transport |
| UniProt Code: | Q8IUH5 |
| NCBI GenInfo Identifier: | 46395885 |
| NCBI Gene ID: | 23390 |
| NCBI Accession: | Q8IUH5.2 |
| UniProt Related Accession: | Q8IUH5 |
| Molecular Weight: | |
| NCBI Full Name: | Palmitoyltransferase ZDHHC17 |
| NCBI Synonym Full Names: | zinc finger DHHC-type containing 17 |
| NCBI Official Symbol: | ZDHHC17 |
| NCBI Official Synonym Symbols: | HIP3; HYPH; HIP14; DHHC-17; HSPC294 |
| NCBI Protein Information: | palmitoyltransferase ZDHHC17 |
| UniProt Protein Name: | Palmitoyltransferase ZDHHC17 |
| UniProt Synonym Protein Names: | Huntingtin yeast partner H; Huntingtin-interacting protein 14; HIP-14; Huntingtin-interacting protein 3; HIP-3; Huntingtin-interacting protein H; Putative MAPK-activating protein PM11; Putative NF-kappa-B-activating protein 205; Zinc finger DHHC domain-containing protein 17; DHHC-17 |
| UniProt Gene Name: | ZDHHC17 |
| UniProt Entry Name: | ZDH17_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZDHHC17 antibody (CAB6793) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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