Epigenetics & Nuclear Signaling Antibodies 2
Anti-ZCCHC11 Antibody (CAB5972)
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- SKU:
- CAB5972
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ZCCHC11 Antibody |
| Antibody SKU: | CAB5972 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ZCCHC11 (NP_001009881.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human ZCCHC11 (NP_001009881.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEES KTLK SENH EPKK NVIC EESK AVQV IGNQ TLKA RNDK SVKE IENS SPNR NSSK KNKQ NDIC IEKT EVKS CKVN AANL PGPK DLGL VLRD QSHC KAKK FPNS PVKA EKAT ISQA KSEK ATSL QAKA EKSP KSPN SVKA EKAS SYQM KSEK VPSS PAEA EKGP SLLL KDMR QKTE LQQI GKKI PSSF TSVD KVNI EAVG GEKC ALQN SPRS QKQQ TCTD NTGD SDDS ASGI EDVS DDLS KMKN DESN KENS SEMD YLEN ATVI DESA LTPE QRLG LKQA EERL ERDH IF |
| Gene ID: | 23318 |
| Uniprot: | Q5TAX3 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 81kDa/185kDa |
| Observed MW: | 185kDa |
| Synonyms: | ZCCHC11, PAPD3, TUT4 |
| Background: |
| UniProt Protein Function: | ZCCHC11: a zinc finger protein that may participate in toll-receptor signaling by suppressing TRAF6-dependent activation of NF-kappaB. Two alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:EC 2.7.7.52; RNA processing; Transferase; Cell development/differentiation Chromosomal Location of Human Ortholog: 1p32.3 Cellular Component: extracellular space; cytoplasm; nucleolus Molecular Function:protein binding; zinc ion binding; RNA uridylyltransferase activity Biological Process: inhibition of NF-kappaB transcription factor; pre-microRNA processing; stem cell maintenance; cytokine production; positive regulation of interleukin-6 production; regulation of lipopolysaccharide-mediated signaling pathway; RNA 3'-end processing |
| NCBI Summary: | ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q5TAX3 |
| NCBI GenInfo Identifier: | 116242850 |
| NCBI Gene ID: | 23318 |
| NCBI Accession: | Q5TAX3.3 |
| UniProt Secondary Accession: | Q5TAX3,Q12764, Q5TAX2, Q5TAX4, Q86XZ3, A2RRP0, B7Z8J5 D3DQ35, |
| UniProt Related Accession: | Q5TAX3 |
| Molecular Weight: | 1644 |
| NCBI Full Name: | Terminal uridylyltransferase 4 |
| NCBI Synonym Full Names: | zinc finger, CCHC domain containing 11 |
| NCBI Official Symbol: | ZCCHC11 |
| NCBI Official Synonym Symbols: | TUT4; PAPD3 |
| NCBI Protein Information: | terminal uridylyltransferase 4; TUTase 4; PAP associated domain containing 3; zinc finger CCHC domain-containing protein 11 |
| UniProt Protein Name: | Terminal uridylyltransferase 4 |
| UniProt Synonym Protein Names: | Zinc finger CCHC domain-containing protein 11 |
| Protein Family: | Terminal uridylyltransferase |
| UniProt Gene Name: | ZCCHC11 |
| UniProt Entry Name: | TUT4_HUMAN |
 | Western blot analysis of extracts of 293T cells, using ZCCHC11 Antibody (CAB5972) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunofluorescence analysis of U2OS cells using ZCCHC11 Rabbit pAb (CAB5972) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using ZCCHC11 Rabbit pAb (CAB5972) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of H9C2 cells using ZCCHC11 Rabbit pAb (CAB5972) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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