Epigenetics & Nuclear Signaling Antibodies 4

Anti-ZBTB20 Antibody (CAB7970)

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SKU:
CAB7970
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:ZBTB20 Rabbit Polyclonal Antibody
Antibody SKU:CAB7970
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human ZBTB20 (NP_056457.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-400 of human ZBTB20 (NP_056457.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ILTA ASIL QIKT VIDE CTRI VSQN VGDV FPGI QDSG QDTP RGTP ESGT SGQS SDTE SGYL QSHP QHSV DRIY SALY ACSM QNGS GERS FYSG AVVS HHET ALGL PRDH HMED PSWI TRIH ERSQ QMER YLST TPET THCR KQPR PVRI QTLV GNIH IKQE MEDD YDYY GQQR VQIL ERNE SEEC TEDT DQAE GTES EPKG ESFD SGVS SSIG TEPD SVEQ QFGP GAAR DSQA EPTQ PEQA AEAP AEGG PQTN QLET GASS PERS NEVE MDST VITV SNSS DKSV LQQP SVNT SIGQ PLPS T
Gene ID:26137
Uniprot:Q9HC78
Cellular Location:Nucleus
Calculated MW:73kDa/81kDa
Observed MW:81kDa
Synonyms:ZBTB20, DPZF, HOF, ODA-8S, PRIMS, ZNF288
Background:This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:ZBTB20: May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function:DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter

Disease: Ossified Ear Cartilages With Mental Deficiency, Muscle Wasting, And Bony Changes

UniProt Code:Q9HC78
NCBI GenInfo Identifier:257900533
NCBI Gene ID:26137
NCBI Accession:NP_001157814.1
UniProt Secondary Accession:Q9HC78,Q63HP6, Q8N6R5, Q9Y410,
UniProt Related Accession:Q9HC78
Molecular Weight:81,083 Da
NCBI Full Name:zinc finger and BTB domain-containing protein 20 isoform 1
NCBI Synonym Full Names:zinc finger and BTB domain containing 20
NCBI Official Symbol:ZBTB20  
NCBI Official Synonym Symbols:HOF; DPZF; ODA-8S; ZNF288  
NCBI Protein Information:zinc finger and BTB domain-containing protein 20; zinc finger protein 288; BTB/POZ zinc finger protein DPZF; dendritic cell-derived BTB/POZ zinc finger
UniProt Protein Name:Zinc finger and BTB domain-containing protein 20
UniProt Synonym Protein Names:Dendritic-derived BTB/POZ zinc finger protein; Zinc finger protein 288
Protein Family:Zinc finger and BTB domain-containing protein
UniProt Gene Name:ZBTB20  
UniProt Entry Name:ZBT20_HUMAN
Anti-ZBTB20 Polyclonal Antibody (CAB7970)Western blot analysis of extracts of various cell lines, using ZBTB20 antibody (CAB7970) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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