Epigenetics & Nuclear Signaling Antibodies 2

Anti-ZBTB18 Antibody (CAB15610)

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SKU:
CAB15610
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-ZBTB18 Antibody
Antibody SKU:CAB15610
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-360 of human ZBTB18 (NP_006343.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 140-360 of human ZBTB18 (NP_006343.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KVES LSDG SSHI AGDL PSDE DEGE DEKL NILP SKRD LAAE PGNM WMRL PSDS AGIP QAGG EAEP HATA AGKT VASP CSST ESLS QRSV TSVR DSAD VDCV LDLS VKSS LSGV ENLN SSYF SSQD VLRS NLVQ VKVE KEAS CDES DVGT NDYD MEHS TVKE SVST NNRV QYEP AHLA PLRE DSVL RELD REDK ASDD EMMT PESE RVQV EGGM ESSL LPYV S
Gene ID:10472
Uniprot:Q99592
Cellular Location:
Calculated MW:58kDa/59kDa
Observed MW:Refer to figures
Synonyms:ZBTB18, C2H2-171, MRD22, RP58, TAZ-1, ZNF238
Background:This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ZNF238: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: intercellular bridge; microtubule cytoskeleton; nuclear chromosome; nucleoplasm; nucleus

Molecular Function:DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; skeletal muscle development

Disease: Mental Retardation, Autosomal Dominant 22

NCBI Summary:This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:Q99592
NCBI GenInfo Identifier:20141020
NCBI Gene ID:10472
NCBI Accession:Q99592.1
UniProt Secondary Accession:Q99592,Q13397, Q5VU40, Q8N463, Q9UD99, A8K5U3,
UniProt Related Accession:Q99592
Molecular Weight:59,366 Da
NCBI Full Name:Zinc finger and BTB domain-containing protein 18
NCBI Synonym Full Names:zinc finger and BTB domain containing 18
NCBI Official Symbol:ZBTB18  
NCBI Official Synonym Symbols:RP58; MRD22; TAZ-1; ZNF238; C2H2-171  
NCBI Protein Information:zinc finger and BTB domain-containing protein 18
UniProt Protein Name:Zinc finger and BTB domain-containing protein 18
UniProt Synonym Protein Names:58 kDa repressor protein; Transcriptional repressor RP58; Translin-associated zinc finger protein 1; TAZ-1; Zinc finger protein 238; Zinc finger protein C2H2-171
Protein Family:Zinc finger and BTB domain-containing protein
UniProt Gene Name:ZBTB18  
UniProt Entry Name:ZBT18_HUMAN
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