Immunology Antibodies 1

Anti-ZBP1 Antibody (CAB13899)

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SKU:
CAB13899
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ZBP1 Antibody
Antibody SKU:CAB13899
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ZBP1 (NP_110403.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:mouse lung, rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ZBP1 (NP_110403.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAQA PADP GREG HLEQ RILQ VLTE AGSP VKLA QLVK ECQA PKRE LNQV LYRM KKEL KVSL TSPA TWCL GGTD PEGE GPAE LALS SPAE RPQQ HAAT IPET PGPQ FSQQ REED IYRF LKDN GPQR ALVI AQAL GMRT AKDV NRDL YRMK SRHL LDMD EQSK AWTI YRPE DSGR RAKS ASII YQHN PINM ICQN GPNS WISI
Gene ID:81030
Uniprot:Q9H171
Cellular Location:
Calculated MW:15kDa/27kDa/38kDa, 41-48kDa
Observed MW:46kDa/60kDa
Synonyms:ZBP1, C20orf183, DAI, DLM-1, DLM1
Background:This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function:double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding

Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response

NCBI Summary:This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9H171
NCBI GenInfo Identifier:71153189
NCBI Gene ID:81030
NCBI Accession:Q9H171.2
UniProt Secondary Accession:Q9H171,Q5JY39, Q9BYW4, A2A2F7, B3KVA1, F5GYT1,
UniProt Related Accession:Q9H171
Molecular Weight:429
NCBI Full Name:Z-DNA-binding protein 1
NCBI Synonym Full Names:Z-DNA binding protein 1
NCBI Official Symbol:ZBP1  
NCBI Official Synonym Symbols:DAI; DLM1; DLM-1; C20orf183  
NCBI Protein Information:Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors
UniProt Protein Name:Z-DNA-binding protein 1
UniProt Synonym Protein Names:Tumor stroma and activated macrophage protein DLM-1
Protein Family:Z-DNA-binding protein
UniProt Gene Name:ZBP1  
UniProt Entry Name:ZBP1_HUMAN
Anti-ZBP1 Antibody (CAB13899)Western blot analysis of extracts of various cell line, using ZBP1 antibody (CAB13899) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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