Immunology Antibodies 3
Anti-ZAP70 Antibody (CAB9536)
- SKU:
- CAB9536
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ZAP70 Antibody |
| Antibody SKU: | CAB9536 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ZAP70 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | Jurkat |
| Immunogen: | A synthesized peptide derived from human ZAP70 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7535 |
| Uniprot: | P43403 |
| Cellular Location: | |
| Calculated MW: | 70kDa |
| Observed MW: | 70KDa |
| Synonyms: | ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70 |
| Background: | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Syk family Chromosomal Location of Human Ortholog: 2q12 Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; immunological synapse; intercellular junction; lipid raft; plasma membrane; T cell receptor complex Molecular Function:ATP binding; non-membrane spanning protein tyrosine kinase activity; phosphotyrosine binding; protein binding; protein-tyrosine kinase activity; receptor binding Biological Process: adaptive immune response; B cell activation; B cell receptor signaling pathway; beta selection; immune response; innate immune response; macrophage activation during immune response; negative thymic T cell selection; neutrophil activation during immune response; peptidyl-tyrosine phosphorylation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of mast cell degranulation; positive regulation of T cell differentiation; positive thymic T cell selection; protein amino acid phosphorylation; T cell activation; T cell differentiation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Selective T-cell Defect |
| NCBI Summary: | This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P43403 |
| NCBI GenInfo Identifier: | 1177044 |
| NCBI Gene ID: | 7535 |
| NCBI Accession: | P43403.1 |
| UniProt Secondary Accession: | P43403,Q6PIA4, Q8IXD6, Q9UBS6, A6NFP4, |
| UniProt Related Accession: | P43403 |
| Molecular Weight: | 55,873 Da |
| NCBI Full Name: | Tyrosine-protein kinase ZAP-70 |
| NCBI Synonym Full Names: | zeta chain of T cell receptor associated protein kinase 70kDa |
| NCBI Official Symbol: | ZAP70 |
| NCBI Official Synonym Symbols: | SRK; STD; TZK; STCD; ZAP-70 |
| NCBI Protein Information: | tyrosine-protein kinase ZAP-70 |
| UniProt Protein Name: | Tyrosine-protein kinase ZAP-70 |
| UniProt Synonym Protein Names: | 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | ZAP70 |
| UniProt Entry Name: | ZAP70_HUMAN |
 | Western blot - ZAP70 Rabbit mAb (CAB9536) |
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