Metabolism Antibodies 2

Anti-YARS2 Antibody (CAB7976)

(No reviews yet) Write a Review
SKU:
CAB7976

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:YARS2 Rabbit Polyclonal Antibody
Antibody SKU:CAB7976
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 228-477 of human YARS2 (NP_001035526.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, SKOV3, HT-29, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 228-477 of human YARS2 (NP_001035526.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DFYY LFQR YGCR VQLG GSDQ LGNI MSGY EFIN KLTG EDVF GITV PLIT STTG AKLG KSAG NAVW LNRD KTSP FELY QFFV RQPD DSVE RYLK LFTF LPLP EIDH IMQL HVKE PERR GPQK RLAA EVTK LVHG REGL DSAK RCTQ ALYH SSID ALEV MSDQ ELKE LFKE APFS EFFL DPGT SVLD TCRK ANAI PDGP RGYR MITE GGVS INHQ QVTN PESV LIVG QHIL KNGL SLLK IGKR NFYI IKWL QL
Gene ID:51067
Uniprot:Q9Y2Z4
Cellular Location:Mitochondrion matrix
Calculated MW:53kDa
Observed MW:53kDa
Synonyms:YARS2, CGI-04, MLASA2, MT-TYRRS, TYRRS
Background:This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2).
UniProt Protein Function:YARS2: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia. Belongs to the class-I aminoacyl-tRNA synthetase family.
UniProt Protein Details:

Protein type:RNA-binding; Ligase; Translation; Mitochondrial; EC 6.1.1.1

Chromosomal Location of Human Ortholog: 12p11.21

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function:protein homodimerization activity; tyrosine-tRNA ligase activity; ATP binding; tRNA binding

Biological Process: tRNA aminoacylation for protein translation; translation; gene expression; tRNA aminoacylation

Disease: Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2

NCBI Summary:This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
UniProt Code:Q9Y2Z4
NCBI GenInfo Identifier:50401709
NCBI Gene ID:51067
NCBI Accession:Q9Y2Z4.2
UniProt Secondary Accession:Q9Y2Z4,Q9H817, D3DUW8,
UniProt Related Accession:Q9Y2Z4
Molecular Weight:477
NCBI Full Name:Tyrosine--tRNA ligase, mitochondrial
NCBI Synonym Full Names:tyrosyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol:YARS2  
NCBI Official Synonym Symbols:TYRRS; CGI-04; MLASA2; MT-TYRRS  
NCBI Protein Information:tyrosine--tRNA ligase, mitochondrial; tyrosine tRNA ligase 2, mitochondrial
UniProt Protein Name:Tyrosine--tRNA ligase, mitochondrial
UniProt Synonym Protein Names:Tyrosyl-tRNA synthetase; TyrRS
UniProt Gene Name:YARS2  
UniProt Entry Name:SYYM_HUMAN
View AllClose

Additional Information

Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
View AllClose

Related Products