Anti-Y14/RBM8A Antibody (CAB19599)
- SKU:
- CAB19599
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- BOV-1A
- Synonyms:
- BOV-1B
- Synonyms:
- BOV-1C
- Synonyms:
- C1DELq21.1
- Synonyms:
- DEL1q21.1
- Synonyms:
- MDS014
- Synonyms:
- RBM8
- Synonyms:
- RBM8B
- Synonyms:
- TAR
- Synonyms:
- Y14
- Synonyms:
- ZNRP
- Synonyms:
- ZRNP1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | Y14/RBM8A Rabbit mAb |
| Product Code: | CAB19599 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | BOV-1A, BOV-1B, BOV-1C, C1DELq21.1, DEL1q21.1, MDS014, RBM8, RBM8B, TAR, Y14, ZNRP, ZRNP1 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Y14/RBM8A |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, 293T, Jurkat, Mouse lung, Mouse brain, Rat lung, Rat brain, Rat spleen |
| Immunogen: | A synthesized peptide derived from human Y14/RBM8A |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9939 |
| Uniprot: | Q9Y5S9 |
| Calculated MW: | 19kDa |
| Observed MW: | 20KDa |
| UniProt Protein Function: | RBM8A: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Remains associated with mRNAs in the cytoplasm until the mRNAs engage the translation machinery. Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex with MAGOH is a component of the nonsense mediated decay (NMD) pathway. Belongs to the RBM8A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; Translation; Spliceosome; RNA-binding Chromosomal Location of Human Ortholog: 1q21.1 Cellular Component: cytosol; nucleoplasm Molecular Function:mRNA binding; protein binding Biological Process: mRNA 3'-end processing; mRNA catabolic process, nonsense-mediated decay; mRNA export from nucleus; nuclear mRNA splicing, via spliceosome; regulation of alternative nuclear mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription Disease: Thrombocytopenia-absent Radius Syndrome |
| NCBI Summary: | This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now thought that the RBM8B locus is a pseudogene. There are two alternate translation start codons with this gene, which result in two forms of the protein. An allele mutation and a low-frequency noncoding single-nucleotide polymorphism (SNP) in this gene cause thrombocytopenia-absent radius (TAR) syndrome. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q9Y5S9 |
| NCBI GenInfo Identifier: | 10720244 |
| NCBI Gene ID: | 9939 |
| NCBI Accession: | Q9Y5S9.1 |
| UniProt Secondary Accession: | Q9Y5S9,Q6FHD1, Q6IQ40, Q9GZX8, Q9NZI4, B3KQI9, |
| UniProt Related Accession: | Q9Y5S9 |
| Molecular Weight: | 19,760 Da |
| NCBI Full Name: | RNA-binding protein 8A |
| NCBI Synonym Full Names: | RNA binding motif protein 8A |
| NCBI Official Symbol: | RBM8A |
| NCBI Official Synonym Symbols: | TAR; Y14; RBM8; ZNRP; RBM8B; ZRNP1; BOV-1A; BOV-1B; BOV-1C; MDS014; DEL1q21.1; C1DELq21.1 |
| NCBI Protein Information: | RNA-binding protein 8A |
| UniProt Protein Name: | RNA-binding protein 8A |
| UniProt Synonym Protein Names: | Binder of OVCA1-1; BOV-1; RNA-binding motif protein 8A; RNA-binding protein Y14; Ribonucleoprotein RBM8A |
| Protein Family: | RNA-binding protein |
| UniProt Gene Name: | RBM8A |
| UniProt Entry Name: | RBM8A_HUMAN |
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