Cell Biology Antibodies 18
Anti-XRN2 Antibody (CAB18350)
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- SKU:
- CAB18350
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-XRN2 Antibody |
| Antibody SKU: | CAB18350 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human XRN2. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | PC-3, A-549 |
| Immunogen: | Recombinant protein of human XRN2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 22803 |
| Uniprot: | Q9H0D6 |
| Cellular Location: | |
| Calculated MW: | 108kDa |
| Observed MW: | 108kDa |
 | Western blot - XRN2 Rabbit pAb (CAB18350) |
| Synonyms: | XRN2 |
| Background: | This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Ribonuclease; Nucleolus; EC 3.1.13.-; RNA-binding; RNA processing Chromosomal Location of Human Ortholog: 20p11.2-p11.1 Cellular Component: membrane; nucleolus; nucleus Molecular Function:5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; protein binding; zinc ion binding Biological Process: cell growth; DNA catabolic process, exonucleolytic; mRNA processing; regulation of transcription, DNA-dependent; RNA catabolic process; RNA metabolic process; RNA processing; spermatogenesis; transcription termination |
| NCBI Summary: | This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9H0D6 |
| NCBI GenInfo Identifier: | 30173484 |
| NCBI Gene ID: | 22803 |
| NCBI Accession: | Q9H0D6.1 |
| UniProt Secondary Accession: | Q9H0D6,Q3L8N4, Q6KGZ9, Q9BQL1, Q9NTW0, Q9NXS6, Q9UL53 |
| UniProt Related Accession: | Q9H0D6 |
| Molecular Weight: | 99,962 Da |
| NCBI Full Name: | 5'-3' exoribonuclease 2 |
| NCBI Synonym Full Names: | 5'-3' exoribonuclease 2 |
| NCBI Official Symbol: | XRN2 |
| NCBI Protein Information: | 5'-3' exoribonuclease 2 |
| UniProt Protein Name: | 5'-3' exoribonuclease 2 |
| UniProt Synonym Protein Names: | DHM1-like protein; DHP protein |
| UniProt Gene Name: | XRN2 |
| UniProt Entry Name: | XRN2_HUMAN |
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