Cell Biology Antibodies 18

Anti-XRN2 Antibody (CAB18350)

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SKU:
CAB18350
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-XRN2 Antibody
Antibody SKU:CAB18350
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human XRN2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:PC-3, A-549
Immunogen:Recombinant protein of human XRN2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:22803
Uniprot:Q9H0D6
Cellular Location:
Calculated MW:108kDa
Observed MW:108kDa
Anti-XRN2 Antibody (CAB18350)Western blot - XRN2 Rabbit pAb (CAB18350)
Synonyms:XRN2
Background:This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation; Ribonuclease; Nucleolus; EC 3.1.13.-; RNA-binding; RNA processing

Chromosomal Location of Human Ortholog: 20p11.2-p11.1

Cellular Component: membrane; nucleolus; nucleus

Molecular Function:5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; protein binding; zinc ion binding

Biological Process: cell growth; DNA catabolic process, exonucleolytic; mRNA processing; regulation of transcription, DNA-dependent; RNA catabolic process; RNA metabolic process; RNA processing; spermatogenesis; transcription termination

NCBI Summary:This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Code:Q9H0D6
NCBI GenInfo Identifier:30173484
NCBI Gene ID:22803
NCBI Accession:Q9H0D6.1
UniProt Secondary Accession:Q9H0D6,Q3L8N4, Q6KGZ9, Q9BQL1, Q9NTW0, Q9NXS6, Q9UL53
UniProt Related Accession:Q9H0D6
Molecular Weight:99,962 Da
NCBI Full Name:5'-3' exoribonuclease 2
NCBI Synonym Full Names:5'-3' exoribonuclease 2
NCBI Official Symbol:XRN2  
NCBI Protein Information:5'-3' exoribonuclease 2
UniProt Protein Name:5'-3' exoribonuclease 2
UniProt Synonym Protein Names:DHM1-like protein; DHP protein
UniProt Gene Name:XRN2  
UniProt Entry Name:XRN2_HUMAN
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