Epigenetics & Nuclear Signaling Antibodies 5

Anti-XRCC1 Antibody (CAB4135)

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SKU:
CAB4135
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-XRCC1 Antibody
Antibody SKU:CAB4135
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human XRCC1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:K-562, Mouse testis, Rat testis
Immunogen:A synthesized peptide derived from human XRCC1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7515
Uniprot:P18887
Cellular Location:
Calculated MW:90kDa
Observed MW:82KDa
Synonyms:RCC
Background:The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
UniProt Protein Function:XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
UniProt Protein Details:

Protein type:DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding; enzyme binding; damaged DNA binding

Biological Process: single strand break repair; base-excision repair; DNA repair

NCBI Summary:The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
UniProt Code:P18887
NCBI GenInfo Identifier:317373290
NCBI Gene ID:7515
NCBI Accession:P18887.2
UniProt Secondary Accession:P18887,Q6IBS4, Q9HCB1,
UniProt Related Accession:P18887
Molecular Weight:69,477 Da
NCBI Full Name:DNA repair protein XRCC1
NCBI Synonym Full Names:X-ray repair complementing defective repair in Chinese hamster cells 1
NCBI Official Symbol:XRCC1  
NCBI Official Synonym Symbols:RCC  
NCBI Protein Information:DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
UniProt Protein Name:DNA repair protein XRCC1
UniProt Synonym Protein Names:X-ray repair cross-complementing protein 1
Protein Family:DNA repair protein
UniProt Gene Name:XRCC1  
UniProt Entry Name:XRCC1_HUMAN
Anti-XRCC1 Antibody (CAB4135)Western blot - XRCC1 Rabbit mAb (CAB4135)
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