ChIP Antibodies

Anti-XPO7 Antibody (CAB16108)

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SKU:
CAB16108
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-XPO7 Antibody
Antibody SKU:CAB16108
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human XPO7 (NP_055839.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:LO2, HT-29, Mouse testis, Mouse spleen, Mouse liver, Rat testis
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1000 to the C-terminus of human XPO7 (NP_055839.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SMSR PLLG LILL NEKY FSDL RNSI VNSQ PPEK QQAM HLCF ENLM EGIE RNLL TKNR DRFT QNLS AFRR EVND SMKN STYG VNSN DMMS
Gene ID:23039
Uniprot:Q9UIA9
Cellular Location:Cytoplasm, Nucleus, nuclear pore complex
Calculated MW:123kDa
Observed MW:124kDa
Synonyms:XPO7, EXP7, RANBP16
Background:The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.
UniProt Protein Function:Exportin-7: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.
UniProt Protein Details:

Protein type:Karyopherin; Nuclear import; Nuclear export

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cytoplasm; nuclear pore; nucleus

Molecular Function:nuclear export signal receptor activity; Ran GTPase binding

Biological Process: mRNA transport; protein export from nucleus

NCBI Summary:The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
UniProt Code:Q9UIA9
NCBI GenInfo Identifier:40225692
NCBI Gene ID:23039
NCBI Accession:AAH14219.1
UniProt Secondary Accession:Q9UIA9,O94846, Q6PJK9, Q8NEK7,
UniProt Related Accession:Q9UIA9
Molecular Weight:123,907 Da
NCBI Full Name:XPO7 protein, partial
NCBI Synonym Full Names:exportin 7
NCBI Official Symbol:XPO7  
NCBI Official Synonym Symbols:EXP7; RANBP16  
NCBI Protein Information:exportin-7; RAN binding protein 16
UniProt Protein Name:Exportin-7
UniProt Synonym Protein Names:Ran-binding protein 16
Protein Family:Exportin
UniProt Gene Name:XPO7  
UniProt Entry Name:XPO7_HUMAN
Anti-XPO7 Antibody (CAB16108)Western blot analysis of extracts of various cell lines, using XPO7 antibody (CAB16108) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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