Cell Biology Antibodies 6
Anti-XPO4 Antibody (CAB15503)
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- SKU:
- CAB15503
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-XPO4 Antibody |
| Antibody SKU: | CAB15503 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human XPO4 (NP_071904.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-700 of human XPO4 (NP_071904.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEAY DKLL ESWL TLVQ DDKH FHKG FFTQ HAVQ VFNS YIQC HLAA PDGT RNLT ANGV ASRE EEEI SELQ EDDR DQFS DQLA SVGM LGRI AAEH CIPL LTSL LEER VTRL HGQL QRHQ QQLL ASPG SSTV DNKM LDDL YEDI HWLI LVTG YLLA DDTQ GETP LIPP EIME YSIK HSSE VDIN TTLQ ILGS PGEK ASSI PGYN RTDS VIRL LSAI LRVS EVES RAIR ADLT HLLS PQMG KDIV WFLK RWAK TYLL VDEK LYDQ ISLP FSTA FGAD TEGS QWII GYLL QKVI SNLS VWSS EQDL A |
| Gene ID: | 64328 |
| Uniprot: | Q9C0E2 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 130kDa |
| Observed MW: | Refer to figures |
| Synonyms: | XPO4, exp4 |
| Background: |
| UniProt Protein Function: | Exportin-4: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family. |
| UniProt Protein Details: | Protein type:Nuclear export; Karyopherin Chromosomal Location of Human Ortholog: 13q11 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding Biological Process: positive regulation of protein export from nucleus; protein transport |
| NCBI Summary: | XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009] |
| UniProt Code: | Q9C0E2 |
| NCBI GenInfo Identifier: | 148886661 |
| NCBI Gene ID: | 64328 |
| NCBI Accession: | NP_071904.4 |
| UniProt Secondary Accession: | Q9C0E2,Q5VUZ5, Q8N3V6, Q9H934, |
| UniProt Related Accession: | Q9C0E2 |
| Molecular Weight: | 130,139 Da |
| NCBI Full Name: | exportin-4 |
| NCBI Synonym Full Names: | exportin 4 |
| NCBI Official Symbol: | XPO4 |
| NCBI Official Synonym Symbols: | exp4 |
| NCBI Protein Information: | exportin-4 |
| UniProt Protein Name: | Exportin-4 |
| Protein Family: | Exportin |
| UniProt Gene Name: | XPO4 |
| UniProt Entry Name: | XPO4_HUMAN |
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