Metabolism Antibodies 1

Anti-XPNPEP1 Antibody (CAB15327)

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SKU:
CAB15327
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-XPNPEP1 Antibody
Antibody SKU:CAB15327
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-240 of human XPNPEP1 (NP_065116.3).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 44-240 of human XPNPEP1 (NP_065116.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPPK VTSE LLRQ LRQA MRNS EYVT EPIQ AYII PSGD AHQS EYIA PCDC RRAF VSGF DGSA GTAI ITEE HAAM WTDG RYFL QAAK QMDS NWTL MKMG LKDT PTQE DWLV SVLP EGSR VGVD PLII PTDY WKKM AKVL RSAG HHLI PVKE NLVD KIWT DRPE RPCK PLLT LGLD YTGI SWKD KVAD LRLK MAER NVMW F
Gene ID:7511
Uniprot:Q9NQW7
Cellular Location:Cytoplasm
Calculated MW:67kDa/69kDa/72kDa/74kDa
Observed MW:90kDa
Synonyms:XPNPEP1, APP1, SAMP, XPNPEP, XPNPEPL, XPNPEPL1
Background:This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:XPNPEP1: Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Belongs to the peptidase M24B family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.11.9; Protease

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: cytoplasm

Molecular Function:aminopeptidase activity; manganese ion binding; protein homodimerization activity

Biological Process: proteolysis

NCBI Summary:This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
UniProt Code:Q9NQW7
NCBI GenInfo Identifier:264681565
NCBI Gene ID:7511
NCBI Accession:NP_001161076.1
UniProt Related Accession:Q9NQW7
Molecular Weight:
NCBI Full Name:xaa-Pro aminopeptidase 1 isoform 2
NCBI Synonym Full Names:X-prolyl aminopeptidase 1
NCBI Official Symbol:XPNPEP1  
NCBI Official Synonym Symbols:APP1; SAMP; XPNPEP; XPNPEPL; XPNPEPL1  
NCBI Protein Information:xaa-Pro aminopeptidase 1
UniProt Protein Name:Xaa-Pro aminopeptidase 1
UniProt Synonym Protein Names:Aminoacylproline aminopeptidase; Cytosolic aminopeptidase P; Soluble aminopeptidase P; sAmp; X-Pro aminopeptidase 1; X-prolyl aminopeptidase 1, soluble
UniProt Gene Name:XPNPEP1  
UniProt Entry Name:XPP1_HUMAN
Anti-XPNPEP1 Antibody (CAB15327)Western blot analysis of extracts of various cell lines, using XPNPEP1 antibody (CAB15327) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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