Signal Transduction Antibodies 2
Anti-XK Antibody (CAB15109)
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- SKU:
- CAB15109
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-XK Antibody |
| Antibody SKU: | CAB15109 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 59-138 of human XK (NP_066569.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse pancreas, rat pancreas |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 59-138 of human XK (NP_066569.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HRDL SRDR PLVL LLHL LQLG PLFR CFEV FCIY FQSG NNEE PYVS ITKK RQMP KNGL SEEI EKEV GQAE GKLI THRS AFSR |
| Gene ID: | 7504 |
| Uniprot: | P51811 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 50kDa |
| Observed MW: | 50kDa |
| Synonyms: | XK, KX, NA, NAC, X1k, XKR1, MCLDS |
| Background: | This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. |
| UniProt Protein Function: | XK: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Defects in XK are the cause of McLeod syndrome (MLS). It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems. Belongs to the XK family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: Xp21.1 Cellular Component: integral to membrane; plasma membrane Molecular Function:protein binding; transporter activity Biological Process: transport Disease: Mcleod Syndrome |
| NCBI Summary: | This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51811 |
| NCBI GenInfo Identifier: | 85700269 |
| NCBI Gene ID: | 7504 |
| NCBI Accession: | P51811.5 |
| UniProt Secondary Accession: | P51811,Q4TTN6, Q8IUK6, Q9UC77, |
| UniProt Related Accession: | P51811 |
| Molecular Weight: | 50,902 Da |
| NCBI Full Name: | Membrane transport protein XK |
| NCBI Synonym Full Names: | X-linked Kx blood group |
| NCBI Official Symbol: | XK |
| NCBI Official Synonym Symbols: | KX; NA; NAC; X1k; XKR1 |
| NCBI Protein Information: | membrane transport protein XK |
| UniProt Protein Name: | Membrane transport protein XK |
| UniProt Synonym Protein Names: | Kell complex 37 kDa component; Kx antigen; XK-related protein 1 |
| Protein Family: | XK-related protein |
| UniProt Gene Name: | XK |
| UniProt Entry Name: | XK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using XK antibody (CAB15109) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunofluorescence analysis of C6 cells using XK antibody (CAB15109) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using XK antibody (CAB15109) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using XK antibody (CAB15109) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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