| Synonyms: | XCL1, ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1 |
| UniProt Protein Function: | XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1q23 Cellular Component: extracellular space; extracellular region Molecular Function:protein homodimerization activity; chemokine activity; chemokine receptor binding Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P47992 |
| NCBI GenInfo Identifier: | 1346471 |
| NCBI Gene ID: | 6375 |
| NCBI Accession: | P47992.1 |
| UniProt Secondary Accession: | P47992,Q52MA8, |
| UniProt Related Accession: | P47992 |
| Molecular Weight: | 12,517 Da |
| NCBI Full Name: | Lymphotactin |
| NCBI Synonym Full Names: | chemokine (C motif) ligand 1 |
| NCBI Official Symbol: | XCL1 |
| NCBI Official Synonym Symbols: | LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a |
| NCBI Protein Information: | lymphotactin; SCM-1-alpha; lymphotaxin; cytokine SCM-1; c motif chemokine 1; XC chemokine ligand 1; single cysteine motif 1a; small-inducible cytokine C1; small inducible cytokine subfamily C, member 1 (lymphotactin) |
| UniProt Protein Name: | Lymphotactin |
| UniProt Synonym Protein Names: | ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1 |
| Protein Family: | Lymphotactin |
| UniProt Gene Name: | XCL1 |
| UniProt Entry Name: | XCL1_HUMAN |
