| UniProt Protein Function: | WRAP53: a protein of unknown function. Contains 6 WD40 domains, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.Chromosomal Location of Human Ortholog: 17p13.1Cellular Component: nucleoplasm; Cajal body; telomerase holoenzyme complex; cytoplasm; nucleusMolecular Function: protein binding; RNA bindingBiological Process: telomere formation via telomerase; positive regulation of telomerase activityDisease: Dyskeratosis Congenita, Autosomal Recessive, 3 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011] |
| UniProt Code: | Q9BUR4 |
| NCBI GenInfo Identifier: | 221136854 |
| NCBI Gene ID: | 55135 |
| NCBI Accession: | NP_060551.2 |
| UniProt Secondary Accession: | Q9BUR4,Q08ET9, Q9NW09, B3KPR9, D3DTQ4 |
| UniProt Related Accession: | Q9BUR4 |
| Molecular Weight: | 59,309 Da |
| NCBI Full Name: | telomerase Cajal body protein 1 |
| NCBI Synonym Full Names: | WD repeat containing, antisense to TP53 |
| NCBI Official Symbol: | WRAP53 |
| NCBI Official Synonym Symbols: | DKCB3; TCAB1; WDR79 |
| NCBI Protein Information: | telomerase Cajal body protein 1 |
| UniProt Protein Name: | Telomerase Cajal body protein 1 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene |
| Protein Family: | Telomerase protein component |
| UniProt Gene Name: | WRAP53 |
| UniProt Entry Name: | WAP53_HUMAN |
