Cell Biology Antibodies 17
Anti-WNK1 Antibody (CAB4223)
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- SKU:
- CAB4223
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WNK1 Antibody |
| Antibody SKU: | CAB4223 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human WNK1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | A synthesized peptide derived from human WNK1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 65125 |
| Uniprot: | Q9H4A3 |
| Cellular Location: | |
| Calculated MW: | 251kDa |
| Observed MW: | 250KDa |
| Synonyms: | HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65 |
| Background: | This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] |
| UniProt Protein Function: | WNK1: a serine-threonine protein kinase that controls sodium and chloride ion transport. May regulate the activity of the thiazide-sensitive Na-Cl cotransporter SLC12A3 by phosphorylation. May also play a role in actin cytoskeletal reorganization. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; Wnk family Chromosomal Location of Human Ortholog: 12p13.3 Cellular Component: cytoplasm Molecular Function:protein serine/threonine kinase activity; protein binding; chloride channel inhibitor activity; protein kinase inhibitor activity; ATP binding; phosphatase binding Biological Process: regulation of cellular process; peptidyl-threonine phosphorylation; negative regulation of protein kinase activity; neuron development; ion transport; protein amino acid phosphorylation Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iia; Pseudohypoaldosteronism, Type Iic |
| NCBI Summary: | This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] |
| UniProt Code: | Q9H4A3 |
| NCBI GenInfo Identifier: | 296453029 |
| NCBI Gene ID: | 65125 |
| NCBI Accession: | Q9H4A3.2 |
| UniProt Secondary Accession: | Q9H4A3,O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673 A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, |
| UniProt Related Accession: | Q9H4A3 |
| Molecular Weight: | 2382 |
| NCBI Full Name: | Serine/threonine-protein kinase WNK1 |
| NCBI Synonym Full Names: | WNK lysine deficient protein kinase 1 |
| NCBI Official Symbol: | WNK1 |
| NCBI Official Synonym Symbols: | KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167 |
| NCBI Protein Information: | serine/threonine-protein kinase WNK1; erythrocyte 65 kDa protein; protein kinase with no lysine 1; prostate-derived sterile 20-like kinase; WNK lysine deficient protein kinase 1 isoform; protein phosphatase 1, regulatory subunit 167 |
| UniProt Protein Name: | Serine/threonine-protein kinase WNK1 |
| UniProt Synonym Protein Names: | Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | WNK1 |
| UniProt Entry Name: | WNK1_HUMAN |
 | Western blot - WNK1 Rabbit mAb (CAB4223) |
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