Immunology Antibodies 1

Anti-WISP3 Antibody (CAB14812)

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SKU:
CAB14812
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-WISP3 Antibody
Antibody SKU:CAB14812
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-260 of human WISP3 (NP_937882.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HT-29, DU145, HepG2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 42-260 of human WISP3 (NP_937882.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TGPL DTTP EGRP GEVS DAPQ RKQF CHWP CKCP QQKP RCPP GVSL VRDG CGCC KICA KQPG EICN EADL CDPH KGLY CDYS VDRP RYET GVCA YLVA VGCE FNQV HYHN GQVF QPNP LFSC LCVS GAIG CTPL FIPK LAGS HCSG AKGG KKSD QSNC SLEP LLQQ LSTS YKTM PAYR NLPL IWKK KCLV QATK WTPC SRTC GMGI SNRV TNEN SNCE MRK
Gene ID:8838
Uniprot:O95389
Cellular Location:Secreted
Calculated MW:39kDa/41kDa
Observed MW:41kDa
Synonyms:WISP3, CCN6, LIBC, PPAC, PPD, WISP-3
Background:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:WISP3: Appears to be required for normal postnatal skeletal growth and cartilage homeostasis. Defects in WISP3 are the cause of progressive pseudorheumatoid arthropathy of childhood (PPAC). PPAC is an autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. Belongs to the CCN family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Cell cycle regulation; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: proteinaceous extracellular matrix

Molecular Function:heparin binding; integrin binding

Biological Process: cell adhesion; cell-cell signaling; signal transduction

Disease: Arthropathy, Progressive Pseudorheumatoid, Of Childhood

NCBI Summary:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:O95389
NCBI GenInfo Identifier:34098394
NCBI Gene ID:8838
NCBI Accession:O95389.1
UniProt Secondary Accession:O95389,Q3KR29, Q5H8W4, Q6UXH6,
UniProt Related Accession:O95389
Molecular Weight:41,402 Da
NCBI Full Name:WNT1-inducible-signaling pathway protein 3
NCBI Synonym Full Names:WNT1 inducible signaling pathway protein 3
NCBI Official Symbol:WISP3  
NCBI Official Synonym Symbols:PPD; CCN6; LIBC; PPAC; WISP-3  
NCBI Protein Information:WNT1-inducible-signaling pathway protein 3
UniProt Protein Name:WNT1-inducible-signaling pathway protein 3
UniProt Synonym Protein Names:CCN family member 6
Protein Family:WNT1-inducible-signaling pathway protein
UniProt Gene Name:WISP3  
UniProt Entry Name:WISP3_HUMAN
Anti-WISP3 Antibody (CAB14812)Western blot analysis of extracts of various cell lines, using WISP3 antibody (CAB14812) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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