Cell Biology Antibodies 3

Anti-WISP2 Antibody (CAB12541)

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SKU:
CAB12541
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-WISP2 Antibody
Antibody SKU:CAB12541
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human WISP2 (NP_003872.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 151-250 of human WISP2 (NP_003872.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VEVL GKCC PEWV CGQG GGLG TQPL PAQG PQFS GLVS SLPP GVPC PEWS TAWG PCST TCGL GMAT RVSN QNRF CRLE TQRR LCLS RPCP PSRG RSPQ NSAF
Gene ID:8839
Uniprot:O76076
Cellular Location:Secreted
Calculated MW:22kDa/26kDa
Observed MW:Refer to figures
Synonyms:WISP2, CCN5, CT58, CTGF-L
Background:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
UniProt Protein Function:WISP2: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Belongs to the CCN family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space; proteinaceous extracellular matrix; plasma membrane

Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding

Biological Process: cell-cell signaling; regulation of cell growth; signal transduction; cell adhesion

NCBI Summary:This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
UniProt Code:O76076
NCBI GenInfo Identifier:24211561
NCBI Gene ID:8839
NCBI Accession:O76076.1
UniProt Secondary Accession:O76076,Q6PEG3, B2R9N4, E1P612,
UniProt Related Accession:O76076
Molecular Weight:Observed: 27kDaCalculated: 22kDa/26kDa
NCBI Full Name:WNT1-inducible-signaling pathway protein 2
NCBI Synonym Full Names:WNT1 inducible signaling pathway protein 2
NCBI Official Symbol:WISP2  
NCBI Official Synonym Symbols:CCN5; CT58; CTGF-L  
NCBI Protein Information:WNT1-inducible-signaling pathway protein 2; WISP-2; CCN family member 5; wnt-1 signaling pathway protein 2; connective tissue growth factor-like protein; connective tissue growth factor-related protein 58
UniProt Protein Name:WNT1-inducible-signaling pathway protein 2
UniProt Synonym Protein Names:CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; Connective tissue growth factor-related protein 58
Protein Family:WNT1-inducible-signaling pathway protein
UniProt Gene Name:WISP2  
UniProt Entry Name:WISP2_HUMAN
Anti-WISP2 Antibody (CAB12541)Immunohistochemistry of paraffin-embedded rat brain using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens).
Anti-WISP2 Antibody (CAB12541)Immunohistochemistry of paraffin-embedded human esophagus using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens).
Anti-WISP2 Antibody (CAB12541)Immunohistochemistry of paraffin-embedded human stomach using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens).
Anti-WISP2 Antibody (CAB12541)Immunohistochemistry of paraffin-embedded mouse brain using WISP2 antibody (CAB12541) at dilution of 1:100 (40x lens).
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