Autophagy Antibodies

Anti-WIPI1 Antibody (CAB9600)

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SKU:
CAB9600
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-WIPI1 Antibody
Antibody SKU:CAB9600
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human WIPI1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, U-87MG, Mouse brain, Mouse kidney, Rat lung, Rat kidney
Immunogen:A synthesized peptide derived from human WIPI1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55062
Uniprot:Q5MNZ9
Cellular Location:
Calculated MW:48kDa
Observed MW:49KDa
Synonyms:ATG18, ATG18A, WIPI49
Background:This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Protein Function:ATG18: May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Autophagy

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cytoplasm; cytosol; endosome membrane; extrinsic to membrane; Golgi membrane; pre-autophagosomal structure membrane; trans-Golgi network

Molecular Function:androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding

Biological Process: autophagic vacuole formation; autophagy; macroautophagy; mitochondrion degradation; protein amino acid lipidation; vesicle targeting, trans-Golgi to endosome

NCBI Summary:This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
UniProt Code:Q5MNZ9
NCBI GenInfo Identifier:146291100
NCBI Gene ID:55062
NCBI Accession:Q5MNZ9.3
UniProt Secondary Accession:Q5MNZ9,Q8IXM5, Q9NWF8,
UniProt Related Accession:Q5MNZ9
Molecular Weight:48,202 Da
NCBI Full Name:WD repeat domain phosphoinositide-interacting protein 1
NCBI Synonym Full Names:WD repeat domain, phosphoinositide interacting 1
NCBI Official Symbol:WIPI1  
NCBI Official Synonym Symbols:ATG18; ATG18A; WIPI49  
NCBI Protein Information:WD repeat domain phosphoinositide-interacting protein 1
UniProt Protein Name:WD repeat domain phosphoinositide-interacting protein 1
UniProt Synonym Protein Names:Atg18 protein homolog; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa
Protein Family:WD repeat domain phosphoinositide-interacting protein
UniProt Gene Name:WIPI1  
UniProt Entry Name:WIPI1_HUMAN
Anti-WIPI1 Antibody (CAB9600)Western blot - WIPI1 Rabbit mAb (CAB9600)
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