Autophagy Antibodies
Anti-WIPI1 Antibody (CAB9600)
- SKU:
- CAB9600
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-WIPI1 Antibody |
| Antibody SKU: | CAB9600 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human WIPI1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, U-87MG, Mouse brain, Mouse kidney, Rat lung, Rat kidney |
| Immunogen: | A synthesized peptide derived from human WIPI1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55062 |
| Uniprot: | Q5MNZ9 |
| Cellular Location: | |
| Calculated MW: | 48kDa |
| Observed MW: | 49KDa |
| Synonyms: | ATG18, ATG18A, WIPI49 |
| Background: | This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Protein Function: | ATG18: May play a role in autophagy. May regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. Probably interacts with androgen (AR) and the estrogen receptor (ER). Binds PtdIns3P and to a lesser extent, PtdIns3,5P2 and PtdIns5P in vitro. Interaction with PtdIns3P is required for recruitment to membranes. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Autophagy Chromosomal Location of Human Ortholog: 17q24.2 Cellular Component: cytoplasm; cytosol; endosome membrane; extrinsic to membrane; Golgi membrane; pre-autophagosomal structure membrane; trans-Golgi network Molecular Function:androgen receptor binding; estrogen receptor binding; phosphatidylinositol 3-phosphate binding; receptor binding Biological Process: autophagic vacuole formation; autophagy; macroautophagy; mitochondrion degradation; protein amino acid lipidation; vesicle targeting, trans-Golgi to endosome |
| NCBI Summary: | This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q5MNZ9 |
| NCBI GenInfo Identifier: | 146291100 |
| NCBI Gene ID: | 55062 |
| NCBI Accession: | Q5MNZ9.3 |
| UniProt Secondary Accession: | Q5MNZ9,Q8IXM5, Q9NWF8, |
| UniProt Related Accession: | Q5MNZ9 |
| Molecular Weight: | 48,202 Da |
| NCBI Full Name: | WD repeat domain phosphoinositide-interacting protein 1 |
| NCBI Synonym Full Names: | WD repeat domain, phosphoinositide interacting 1 |
| NCBI Official Symbol: | WIPI1 |
| NCBI Official Synonym Symbols: | ATG18; ATG18A; WIPI49 |
| NCBI Protein Information: | WD repeat domain phosphoinositide-interacting protein 1 |
| UniProt Protein Name: | WD repeat domain phosphoinositide-interacting protein 1 |
| UniProt Synonym Protein Names: | Atg18 protein homolog; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa |
| Protein Family: | WD repeat domain phosphoinositide-interacting protein |
| UniProt Gene Name: | WIPI1 |
| UniProt Entry Name: | WIPI1_HUMAN |
 | Western blot - WIPI1 Rabbit mAb (CAB9600) |
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