Epigenetics & Nuclear Signaling Antibodies 3

Anti-WHSC1L1 Antibody (CAB2317)

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SKU:
CAB2317
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-WHSC1L1 Antibody
Antibody SKU:CAB2317
Antibody Size:100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide of human WHSC1L1
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293, HeLa
Immunogen:A synthetic peptide of human WHSC1L1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54904
Uniprot:Q9BZ95
Cellular Location:Chromosome, Nucleus
Calculated MW:72kDa/154kDa/156kDa/160kDa/161kDa
Observed MW:85kDa
Synonyms:NSD3, KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328
Background:This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described.
UniProt Protein Function:WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - lysine degradation; Methyltransferase, protein lysine; Oncoprotein; Histone-binding; EC 2.1.1.43; Methyltransferase

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function:protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; negative regulation of transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid

NCBI Summary:This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]
UniProt Code:Q9BZ95
NCBI GenInfo Identifier:74761342
NCBI Gene ID:54904
NCBI Accession:Q9BZ95.1
UniProt Secondary Accession:Q9BZ95,Q6P2L6,
UniProt Related Accession:Q9BZ95
Molecular Weight:162kDa
NCBI Full Name:Histone-lysine N-methyltransferase NSD3
NCBI Synonym Full Names:nuclear receptor binding SET domain protein 3
NCBI Official Symbol:NSD3  
NCBI Official Synonym Symbols:KMT3F; KMT3G; WHISTLE; WHSC1L1; pp14328  
NCBI Protein Information:histone-lysine N-methyltransferase NSD3
UniProt Protein Name:Histone-lysine N-methyltransferase NSD3
UniProt Synonym Protein Names:Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like protein 1
UniProt Gene Name:WHSC1L1  
UniProt Entry Name:NSD3_HUMAN
Anti-WHSC1L1 Antibody (CAB2317)Western blot analysis of extracts of various cell lines, using WHSC1L1 antibody (CAB2317). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
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