Cell Biology Antibodies 17
Anti-WDR83 Antibody (CAB18510)
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- SKU:
- CAB18510
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WDR83 Antibody |
| Antibody SKU: | CAB18510 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human WDR83. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human WDR83. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84292 |
| Uniprot: | Q9BRX9 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | MORG1, WDR83 |
| Background: |
| UniProt Protein Function: | MORG1: Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator. May also be involved in pre-mRNA splicing. Belongs to the WD repeat MORG1 family. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA processing Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: spliceosome; cytoplasm Molecular Function:protein binding Biological Process: RNA splicing, via transesterification reactions; nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BRX9 |
| NCBI GenInfo Identifier: | 74761224 |
| NCBI Gene ID: | 84292 |
| NCBI Accession: | Q9BRX9.1 |
| UniProt Related Accession: | Q9BRX9 |
| Molecular Weight: | 34kDa |
| NCBI Full Name: | WD repeat domain-containing protein 83 |
| NCBI Synonym Full Names: | WD repeat domain 83 |
| NCBI Official Symbol: | WDR83 |
| NCBI Official Synonym Symbols: | MORG1 |
| NCBI Protein Information: | WD repeat domain-containing protein 83 |
| UniProt Protein Name: | WD repeat domain-containing protein 83 |
| UniProt Synonym Protein Names: | Mitogen-activated protein kinase organizer 1; MAPK organizer 1 |
| Protein Family: | WD repeat domain-containing protein |
| UniProt Gene Name: | WDR83 |
| UniProt Entry Name: | WDR83_HUMAN |
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