Anti-WDR4 Antibody (CAB19765)
- SKU:
- CAB19765
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TRM82
- Synonyms:
- TRMT82
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | WDR4 Rabbit mAb |
| Product Code: | CAB19765 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | TRM82, TRMT82 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human WDR4 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, A-549, Mouse lung, Mouse spleen, Mouse kidney, Rat kidney |
| Immunogen: | A synthesized peptide derived from human WDR4 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10785 |
| Uniprot: | P57081 |
| Calculated MW: | 45kDa |
| Observed MW: | 73KDa |
| UniProt Protein Function: | WDR4: a WD40 repeat protein. Required for 7-methylguanosine modification of tRNA. Forms a complex with METTL1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding; tRNA (guanine-N7-)-methyltransferase activity Biological Process: tRNA modification |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P57081 |
| NCBI GenInfo Identifier: | 20141943 |
| NCBI Gene ID: | 10785 |
| NCBI Accession: | P57081.2 |
| UniProt Secondary Accession: | P57081,Q9BVM5, Q9HCR3, A8KA58, B2RCA3, B4DNQ7, D3DSK3 |
| UniProt Related Accession: | P57081 |
| Molecular Weight: | 29,946 Da |
| NCBI Full Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 |
| NCBI Synonym Full Names: | WD repeat domain 4 |
| NCBI Official Symbol: | WDR4 |
| NCBI Official Synonym Symbols: | TRM82; TRMT82 |
| NCBI Protein Information: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 |
| UniProt Protein Name: | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 4 |
| Protein Family: | tRNA |
| UniProt Gene Name: | WDR4 |
| UniProt Entry Name: | WDR4_HUMAN |
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