Cell Biology Antibodies 6
Anti-WDR36 Antibody (CAB15566)
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- SKU:
- CAB15566
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WDR36 Antibody |
| Antibody SKU: | CAB15566 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 702-951 of human WDR36 (NP_644810.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 702-951 of human WDR36 (NP_644810.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRPL PADY VPSI VMLP GTCQ TQDV EVSE ETVE PSDE LIEY DSPE QLNE QLVT LSLL PESR WKNL LNLD VIKK KNKP KEPP KVPK SAPF FIPT IPGL VPRY AAPE QNND PQQS KVVN LGVL AQKS DFCL KLEE GLVN NKYD TALN LLKE SGPS GIET ELRS LSPD CGGS IEVM QSFL KMIG MMLD RKRD FELA QAYL ALFL KLHL KMLP SEPV LLEE ITNL SSQV EENW THLQ SLFN QSMC ILNY LKSA LL |
| Gene ID: | 134430 |
| Uniprot: | Q8NI36 |
| Cellular Location: | Nucleus, nucleolus |
| Calculated MW: | 105kDa |
| Observed MW: | Refer to figures |
| Synonyms: | WDR36, GLC1G, TA-WDRP, TAWDRP, UTP21 |
| Background: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). |
| UniProt Protein Function: | WDR36: Involved in T-cell activation and highly co-regulated with IL2. Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 5q22.1 Cellular Component: small subunit processome; nucleolus Biological Process: retinal homeostasis; visual perception; response to stimulus; regulation of axon extension; rRNA processing Disease: Glaucoma 1, Open Angle, G |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NI36 |
| NCBI GenInfo Identifier: | 21281677 |
| NCBI Gene ID: | 134430 |
| NCBI Accession: | NP_644810.1 |
| UniProt Secondary Accession: | Q8NI36,Q68E02, Q8N1Q2, A2RUS4, |
| UniProt Related Accession: | Q8NI36 |
| Molecular Weight: | 105kd |
| NCBI Full Name: | WD repeat-containing protein 36 |
| NCBI Synonym Full Names: | WD repeat domain 36 |
| NCBI Official Symbol: | WDR36 |
| NCBI Official Synonym Symbols: | GLC1G; UTP21; TAWDRP; TA-WDRP |
| NCBI Protein Information: | WD repeat-containing protein 36 |
| UniProt Protein Name: | WD repeat-containing protein 36 |
| UniProt Synonym Protein Names: | T-cell activation WD repeat-containing protein; TA-WDRP |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR36 |
| UniProt Entry Name: | WDR36_HUMAN |
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