Cell Biology Antibodies 2
Anti-WDR1 Antibody (CAB12163)
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- SKU:
- CAB12163
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-WDR1 Antibody |
| Antibody SKU: | CAB12163 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human WDR1 (NP_059830.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Raji, HT-29, U-87MG, MCF7, NIH/3T3, Mouse brain, Mouse liver, Rat heart, Rat spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human WDR1 (NP_059830.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YINY LDRN NPSK PLHV IKGH SKSI QCLT VHKN GGKS YIYS GSHD GHIN YWDS ETGE NDSF AGKG HTNQ VSRM TVDE SGQL ISCS MDDT VRYT SLML RDYS GQGV VKLD VQPK CVAV GPGG YAVV VCIG QIVL LKDQ RKCF SIDN PGYE PEVV AVHP GGDT VAIG GVDG NVRL YSIL GTTL KDEG KLLE AKGP VTDV AYSH D |
| Gene ID: | 9948 |
| Uniprot: | O75083 |
| Cellular Location: | Cell projection, Cytoplasm, cytoskeleton, podosome |
| Calculated MW: | 50kDa/66kDa |
| Observed MW: | 68kDa |
| Synonyms: | WDR1, AIP1, HEL-S-52, NORI-1 |
| Background: | This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | WDR1: a WD40 repeat cytoskeletal protein that induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Three alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Protein type:Actin-binding Chromosomal Location of Human Ortholog: 4p16.1 Cellular Component: cortical actin cytoskeleton; cytosol; extracellular region; intercellular junction Molecular Function:actin filament binding Biological Process: apical junction assembly; locomotion; maintenance of epithelial cell polarity; platelet degranulation; positive regulation of actin filament depolymerization; regulation of actin filament depolymerization; sarcomere organization; sensory perception of sound |
| NCBI Summary: | This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75083 |
| NCBI GenInfo Identifier: | 12643636 |
| NCBI Gene ID: | 9948 |
| NCBI Accession: | O75083.4 |
| UniProt Secondary Accession: | O75083,O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0, A8K6E9 A8MPU4, |
| UniProt Related Accession: | O75083 |
| Molecular Weight: | 66kDa |
| NCBI Full Name: | WD repeat-containing protein 1 |
| NCBI Synonym Full Names: | WD repeat domain 1 |
| NCBI Official Symbol: | WDR1 |
| NCBI Official Synonym Symbols: | AIP1; NORI-1; HEL-S-52 |
| NCBI Protein Information: | WD repeat-containing protein 1 |
| UniProt Protein Name: | WD repeat-containing protein 1 |
| UniProt Synonym Protein Names: | Actin-interacting protein 1; AIP1; NORI-1 |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR1 |
 | Western blot analysis of extracts of various cell lines, using WDR1 antibody (CAB12163) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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