Cell Biology Antibodies 2
Anti-WDFY2 Antibody (CAB10598)
- SKU:
- CAB10598
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Antibody Name: | Anti-WDFY2 Antibody |
Antibody SKU: | CAB10598 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human WDFY2 (NP_443182.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | NCI-H460, HepG2 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human WDFY2 (NP_443182.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | MAAE IQPK PLTR KPIL LQRM EGSQ EVVN MAVI VPKE EGVI SVSE DRTV RVWL KRDS GQYW PSVY HAMP SPCS CMSF NPET RRLS IGLD NGTI SEFI LSED YNKM TPVK NYQA HQSR VTMI LFVL ELEW VLST GQDK QFAW HCSE SGQR LGGY RTSA VASG LQFD VETR HVFI GDHS GQVT ILKL EQEN CTLV TTFR GHTG |
Gene ID: | 115825 |
Uniprot: | Q96P53 |
Cellular Location: | Cytoplasm, Early endosome, Endosome |
Calculated MW: | 45kDa |
Observed MW: | 45kDa |
Synonyms: | WDFY2, PROF, WDF2, ZFYVE22 |
Background: | This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. |
UniProt Protein Function: | WDFY2: Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (PubMed:17313651). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates. Participates in transferrin receptor endocytosis (PubMed:16873553). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16873553, ECO:0000269|PubMed:17313651, ECO:0000269|PubMed:18388859}. Homodimer (PubMed:16792529). Interacts (via WD repeats 1- 3) with AKT1, AKT2, PRKCZ and PRKCI (PubMed:16792529). Interacts with VAMP2 (PubMed:17313651). Forms a complex with VAMP2 and PRKCZ (PubMed:17313651). Interacts with FOXO1. Forms a complex with AKT1 and FOXO1. {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651} |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q14.3 Cellular Component: early endosome; vesicle Molecular Function:protein binding Biological Process: positive regulation of fat cell differentiation; positive regulation of protein amino acid phosphorylation |
NCBI Summary: | This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96P53 |
NCBI GenInfo Identifier: | 51316902 |
NCBI Gene ID: | 115825 |
NCBI Accession: | Q96P53.2 |
UniProt Secondary Accession: | Q96P53,Q96CS1, B1AL86, |
UniProt Related Accession: | Q96P53 |
Molecular Weight: | 45kDa |
NCBI Full Name: | WD repeat and FYVE domain-containing protein 2 |
NCBI Synonym Full Names: | WD repeat and FYVE domain containing 2 |
NCBI Official Symbol: | WDFY2 |
NCBI Official Synonym Symbols: | PROF; WDF2; ZFYVE22 |
NCBI Protein Information: | WD repeat and FYVE domain-containing protein 2 |
UniProt Protein Name: | WD repeat and FYVE domain-containing protein 2 |
UniProt Synonym Protein Names: | Propeller-FYVE protein |
UniProt Gene Name: | WDFY2 |
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