Description
| Antibody Name: | Anti-WASL Antibody |
| Antibody SKU: | CAB2270 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human WASL |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain, HeLa |
| Immunogen: | A synthesized peptide derived from human WASL |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8976 |
| Uniprot: | O00401 |
| Cellular Location: | |
| Calculated MW: | 55kDa |
| Observed MW: | 70KDa |
| Synonyms: | N-WASP, NWASP, WASPB |
| Background: | This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013] |
| UniProt Protein Function: | N-WASP: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1. Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7q31.3 Cellular Component: lamellipodium; cytoplasmic membrane-bound vesicle; plasma membrane; actin cap; nucleus; cytosol; actin cytoskeleton Molecular Function:protein binding; actin binding Biological Process: positive regulation of filopodium formation; axon guidance; mitosis; transcription, DNA-dependent; vesicle organization and biogenesis; nitric oxide metabolic process; spindle localization; vesicle transport along actin filament; regulation of protein localization; regulation of transcription, DNA-dependent; response to bacterium; cell division; actin polymerization and/or depolymerization; ephrin receptor signaling pathway; innate immune response; protein complex assembly; regulation of nitric-oxide synthase activity; cell motility; membrane budding |
| NCBI Summary: | This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013] |
| UniProt Code: | O00401 |
| NCBI GenInfo Identifier: | 62291053 |
| NCBI Gene ID: | 8976 |
| NCBI Accession: | O00401.2 |
| UniProt Secondary Accession: | O00401,Q7Z746, A1JUI9, |
| UniProt Related Accession: | O00401 |
| Molecular Weight: | 505 |
| NCBI Full Name: | Neural Wiskott-Aldrich syndrome protein |
| NCBI Synonym Full Names: | Wiskott-Aldrich syndrome-like |
| NCBI Official Symbol: | WASL |
| NCBI Official Synonym Symbols: | NWASP; N-WASP |
| NCBI Protein Information: | neural Wiskott-Aldrich syndrome protein |
| UniProt Protein Name: | Neural Wiskott-Aldrich syndrome protein |
| Protein Family: | Neural Wiskott-Aldrich syndrome protein |
| UniProt Gene Name: | WASL |
| UniProt Entry Name: | WASL_HUMAN |
 | Western blot - WASL Rabbit mAb (CAB2270) |
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