Cell Biology Antibodies 10
Anti-VTI1B Antibody (CAB7062)
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- SKU:
- CAB7062
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-VTI1B Antibody |
| Antibody SKU: | CAB7062 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human VTI1B (NP_006361.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human VTI1B (NP_006361.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MASS AASS EHFE KLHE IFRG LHED LQGV PERL LGTA GTEE KKKL IRDF DEKQ QEAN ETLA EMEE ELRY APLS FRNP MMSK LRNY RKDL AKLH REVR STPL TATP GGRG DMKY GIYA VENE HMNR LQSQ RAML LQGT ESLN RATQ SIER SHRI ATET DQIG SEII EELG EQRD QLER TKSR LVNT SENL SKSR KILR SMSR KVTT NKLL LS |
| Gene ID: | 10490 |
| Uniprot: | Q9UEU0 |
| Cellular Location: | Cytoplasmic granule, Late endosome membrane, Lysosome membrane, Single-pass type IV membrane protein |
| Calculated MW: | 19kDa/26kDa |
| Observed MW: | 27kDa |
| Synonyms: | VTI1B, VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1 |
| Background: |
| UniProt Protein Function: | VTI1B: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 14q24.1 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; integral to membrane; SNARE complex; synaptic vesicle; recycling endosome; cell soma; perinuclear region of cytoplasm; cytoplasm; vesicle Molecular Function:SNAP receptor activity; SNARE binding; chloride channel inhibitor activity Biological Process: vesicle-mediated transport; intra-Golgi vesicle-mediated transport; cell proliferation; ER to Golgi vesicle-mediated transport; autophagic vacuole fusion; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle docking during exocytosis |
| UniProt Code: | Q9UEU0 |
| NCBI GenInfo Identifier: | 126302613 |
| NCBI Gene ID: | 10490 |
| NCBI Accession: | Q9UEU0.3 |
| UniProt Secondary Accession: | Q9UEU0,O43547, Q96J28, |
| UniProt Related Accession: | Q9UEU0 |
| Molecular Weight: | 232 |
| NCBI Full Name: | Vesicle transport through interaction with t-SNAREs homolog 1B |
| NCBI Synonym Full Names: | vesicle transport through interaction with t-SNAREs 1B |
| NCBI Official Symbol: | VTI1B |
| NCBI Official Synonym Symbols: | VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE |
| NCBI Protein Information: | vesicle transport through interaction with t-SNAREs homolog 1B; vesicle transport v-SNARE protein Vti1-like 1; vesicle-associated soluble NSF attachment protein receptor |
| UniProt Protein Name: | Vesicle transport through interaction with t-SNAREs homolog 1B |
| UniProt Synonym Protein Names: | Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1 |
| Protein Family: | Vesicle transport through interaction with t-SNAREs |
| UniProt Gene Name: | VTI1B |
| UniProt Entry Name: | VTI1B_HUMAN |
 | Western blot analysis of extracts of mouse brain, using VTI1B antibody (CAB7062) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using VTI1B antibody (CAB7062) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal cancer using VTI1B antibody (CAB7062) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using VTI1B antibody (CAB7062). Blue: DAPI for nuclear staining. |
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