Cell Biology Antibodies 8

Anti-VSNL1 Antibody (CAB2797)

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SKU:
CAB2797
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-VSNL1 Antibody
Antibody SKU:CAB2797
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human VSNL1 (NP_003376.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:THP-1, A673, Mouse heart, Mouse brain, Mouse lung, Rat lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human VSNL1 (NP_003376.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGKQ NSKL APEV MEDL VKST EFNE HELK QWYK GFLK DCPS GRLN LEEF QQLY VKFF PYGD ASKF AQHA FRTF DKNG DGTI DFRE FICA LSIT SRGS FEQK LNWA FNMY DLDG DGKI TRVE MLEI IEAI YKMV GTVI MMKM NEDG LTPE QRVD KIFS KMDK NKDD QITL DEFK EAAK SDPS IVLL LQCD IQK
Gene ID:7447
Uniprot:P62760
Cellular Location:
Calculated MW:22kDa
Observed MW:18kDa
Synonyms:VSNL1, HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1
Background:This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
UniProt Protein Function:VSNL1: Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. Belongs to the recoverin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 2p24.3

Molecular Function:calcium ion binding

Biological Process: calcium-mediated signaling

NCBI Summary:This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P62760
NCBI GenInfo Identifier:51338696
NCBI Gene ID:7447
NCBI Accession:P62760.2
UniProt Secondary Accession:P62760,P28677, P29103, P42323, Q9UM20, D6W515,
UniProt Related Accession:P62760
Molecular Weight:191
NCBI Full Name:Visinin-like protein 1
NCBI Synonym Full Names:visinin-like 1
NCBI Official Symbol:VSNL1  
NCBI Official Synonym Symbols:HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1  
NCBI Protein Information:visinin-like protein 1; VLP-1; hippocalcin-like protein 3
UniProt Protein Name:Visinin-like protein 1
UniProt Synonym Protein Names:Hippocalcin-like protein 3; HLP3
Protein Family:Visinin-like protein
UniProt Gene Name:VSNL1  
UniProt Entry Name:VISL1_HUMAN
Anti-VSNL1 Antibody (CAB2797)Western blot analysis of extracts of various cell lines, using VSNL1 Antibody (CAB2797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-VSNL1 Antibody (CAB2797)Immunofluorescence analysis of U2OS cells using VSNL1 antibody (CAB2797). Blue: DAPI for nuclear staining.
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