Immunology Antibodies 1
Anti-VRK2 Antibody (CAB12243)
- SKU:
- CAB12243
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Antibody Name: | Anti-VRK2 Antibody |
Antibody SKU: | CAB12243 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-508 of human VRK2 (NP_006287.2). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human |
Positive Samples: | LO2 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 269-508 of human VRK2 (NP_006287.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | DELP QSVL KWAP SGSS CCEI AQFL VCAH SLAY DEKP NYQA LKKI LNPH GIPL GPLD FSTK GQSI NVHT PNSQ KVDS QKAA TKQV NKAH NRLI EKKV HSER SAES CATW KVQK EEKL IGLM NNEA AQES TRRR QKYQ ESQE PLNE VNSF PQKI SYTQ FPNS FYEP HQDF TSPD IFKK SRSP SWYK YTST VSTG ITDL ESST GLWP TISQ FTLS EETN ADVY YYRI IIPV LLML VFLA LFFL |
Gene ID: | 7444 |
Uniprot: | Q86Y07 |
Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Mitochondrion membrane, Nucleus, Single-pass type IV membrane protein |
Calculated MW: | 44kDa/45kDa/55kDa/58kDa |
Observed MW: | 54kDa |
Synonyms: | VRK2 |
Background: | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. |
UniProt Protein Function: | Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant. |
NCBI Summary: | This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014] |
UniProt Code: | Q86Y07 |
NCBI GenInfo Identifier: | 90116515 |
NCBI Gene ID: | 7444 |
NCBI Accession: | Q86Y07.3 |
UniProt Secondary Accession: | Q86Y07,Q49AK9, Q53EU9, Q53S39, Q53S77, Q53TU1, Q86Y08 Q86Y09, Q86Y10, B4DKL0, D6W5D4, D6W5D6, |
UniProt Related Accession: | Q86Y07 |
Molecular Weight: | 58kDa |
NCBI Full Name: | Serine/threonine-protein kinase VRK2 |
NCBI Synonym Full Names: | vaccinia related kinase 2 |
NCBI Official Symbol: | VRK2 |
NCBI Protein Information: | serine/threonine-protein kinase VRK2 |
UniProt Protein Name: | Serine/threonine-protein kinase VRK2 |
UniProt Synonym Protein Names: | Vaccinia-related kinase 2 |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | VRK2 |
View AllClose