Cell Biology Antibodies 6
Anti-VPS51 Antibody (CAB15651)
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- SKU:
- CAB15651
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-VPS51 Antibody |
| Antibody SKU: | CAB15651 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human VPS51 (NP_037397.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human VPS51 (NP_037397.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA AAAG PSPG SGPG DSPE GPEG EAPE RRRK AHGM LKLY YGLS EGEA AGRP AGPD PLDP TDLN GAHF DPEV YLDK LRRE CPLA QLMD SETD MVRQ IRAL DSDM QTLV YENY NKFI SATD TIRK MKND FRKM EDEM DRLA TNMA VITD FSAR ISAT LQDR HERI TKLA GVHA LLRK LQFL FELP SRLT KCVE LGAY GQAV RYQG RAQA VLQQ YQHL PSFR AIQD DCQV ITAR LAQQ LRQR FREG GSGA PEQA ECVE LLLA |
| Gene ID: | 738 |
| Uniprot: | Q9UID3 |
| Cellular Location: | Golgi apparatus, Recycling endosome, trans-Golgi network |
| Calculated MW: | 72kDa/86kDa |
| Observed MW: | 100kDa |
| Synonyms: | VPS51, ANG2, ANG3, C11orf2, C11orf3, FFR |
| Background: | This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). |
| NCBI Summary: | This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9UID3 |
| NCBI GenInfo Identifier: | 8393009 |
| NCBI Gene ID: | 738 |
| NCBI Accession: | NP_037397.2 |
| UniProt Secondary Accession: | Q9UID3,Q6PJV5, Q7L8A6, Q8WZ35, Q96DF4, Q96GR3, |
| UniProt Related Accession: | Q9UID3 |
| Molecular Weight: | 72,655 Da |
| NCBI Full Name: | vacuolar protein sorting-associated protein 51 homolog |
| NCBI Synonym Full Names: | VPS51, GARP complex subunit |
| NCBI Official Symbol: | VPS51 |
| NCBI Official Synonym Symbols: | FFR; ANG2; ANG3; C11orf2; C11orf3 |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 51 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 51 homolog |
| UniProt Synonym Protein Names: | Another new gene 2 protein; Protein fat-free homolog |
| UniProt Gene Name: | VPS51 |
 | Western blot analysis of extracts of A-549 cells, using VPS51 antibody (CAB15651) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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