Cell Biology Antibodies 14

Anti-VPS45 Antibody (CAB17941)

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SKU:
CAB17941
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-VPS45 Antibody
Antibody SKU:CAB17941
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human VPS45
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human
Positive Samples:
Immunogen:A synthetic Peptide of human VPS45
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11311
Uniprot:Q9NRW7
Cellular Location:Endosome membrane, Golgi apparatus membrane, Peripheral membrane protein
Calculated MW:61kDa/65kDa
Observed MW:Refer to figures
Synonyms:VPS45, H1, H1VPS45, SCN5, VPS45A, VPS45B, VPS54A, VSP45, VSP45A
Background:Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:VPS45A: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Belongs to the STXBP/unc-18/SEC1 family.
UniProt Protein Details:

Protein type:Vesicle

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: Golgi membrane; Golgi apparatus; integral to membrane; endosome membrane

Biological Process: intracellular protein transport; blood coagulation; vesicle docking during exocytosis

Disease: Neutropenia, Severe Congenital, 5, Autosomal Recessive

NCBI Summary:Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
UniProt Code:Q9NRW7
NCBI GenInfo Identifier:23396937
NCBI Gene ID:11311
NCBI Accession:Q9NRW7.1
UniProt Secondary Accession:Q9NRW7,Q15715, Q53FR8, Q5T4P6, Q9Y4Z6, D3DUZ9, F5H8K1
UniProt Related Accession:Q9NRW7
Molecular Weight:570
NCBI Full Name:Vacuolar protein sorting-associated protein 45
NCBI Synonym Full Names:vacuolar protein sorting 45 homolog (S. cerevisiae)
NCBI Official Symbol:VPS45  
NCBI Official Synonym Symbols:H1; SCN5; VSP45; VPS45A; VPS45B; VPS54A; VSP45A; H1VPS45  
NCBI Protein Information:vacuolar protein sorting-associated protein 45; hlVps45; vacuolar protein sorting 45A; leucocyte vacuolar protein sorting 45
UniProt Protein Name:Vacuolar protein sorting-associated protein 45
Protein Family:Vacuolar protein sorting-associated protein
UniProt Gene Name:VPS45  
UniProt Entry Name:VPS45_HUMAN
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