Immunology Antibodies 1
Anti-VPS29 Antibody (CAB13098)
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- SKU:
- CAB13098
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-VPS29 Antibody |
| Antibody SKU: | CAB13098 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human VPS29 (NP_476528.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-29, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-186 of human VPS29 (NP_476528.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGH RLVL VLGD LHIP HRCN SLPA KFKK LLVP GKIQ HILC TGNL CTKE SYDY LKTL AGDV HIVR GDFD ENLN YPEQ KVVT VGQF KIGL IHGH QVIP WGDM ASLA LLQR QFDV DILI SGHT HKFE AFEH ENKF YINP GSAT GAYN ALET NIIP SFVL MDIQ ASTV VTYV YQLI GDDV KVER IEYK KP |
| Gene ID: | 51699 |
| Uniprot: | Q9UBQ0 |
| Cellular Location: | Cytoplasm, Early endosome, Endosome membrane, Late endosome, Membrane, Peripheral membrane protein |
| Calculated MW: | 20kDa |
| Observed MW: | 20kDa |
| Synonyms: | VPS29, DC15, DC7, PEP11 |
| Background: | This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. |
| UniProt Protein Function: | VPS29: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Belongs to the VPS29 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, Ser/Thr (non-receptor); Vesicle; EC 3.1.3.3 Chromosomal Location of Human Ortholog: 12q24 Cellular Component: intracellular membrane-bound organelle; retromer complex; cytoplasm; late endosome; early endosome; endosome membrane; cytosol; endosome Molecular Function:protein binding; zinc ion binding; protein transporter activity Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi |
| NCBI Summary: | This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9UBQ0 |
| NCBI GenInfo Identifier: | 25453325 |
| NCBI Gene ID: | 51699 |
| NCBI Accession: | Q9UBQ0.1 |
| UniProt Secondary Accession: | Q9UBQ0,Q502Y5, Q6FIF8, Q6IAH3, Q9H0W0, Q9NRP1, Q9NRU7 |
| UniProt Related Accession: | Q9UBQ0 |
| Molecular Weight: | 20,927 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 29 |
| NCBI Synonym Full Names: | vacuolar protein sorting 29 homolog (S. cerevisiae) |
| NCBI Official Symbol: | VPS29 |
| NCBI Official Synonym Symbols: | DC7; DC15; PEP11 |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 29; hVPS29; PEP11 homolog; x 007 protein; retromer protein; vesicle protein sorting 29; vacuolar sorting protein VPS29/PEP11 |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 29 |
| UniProt Synonym Protein Names: | PEP11 homolog; Vesicle protein sorting 29 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS29 |
| UniProt Entry Name: | VPS29_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VPS29 antibody (CAB13098) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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