| UniProt Protein Function: | VPS11: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Belongs to the VPS11 family.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11q23Cellular Component: early endosome; endocytic vesicle; endosome; late endosome; lysosomal membrane; lysosomeMolecular Function: protein binding; protein binding, bridging; protein domain specific binding; syntaxin bindingBiological Process: endosomal vesicle fusion; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis; regulation of protein stability; vesicle docking during exocytosis |
| UniProt Protein Details: | |
| NCBI Summary: | Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9H270 |
| NCBI GenInfo Identifier: | 23396928 |
| NCBI Gene ID: | 55823 |
| NCBI Accession: | Q9H270.1 |
| UniProt Secondary Accession: | Q9H270,Q8WY89, Q96EP8, Q9H6D9, Q9HCS6 |
| UniProt Related Accession: | Q9H270 |
| Molecular Weight: | 107,837 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 11 homolog |
| NCBI Synonym Full Names: | VPS11, CORVET/HOPS core subunit |
| NCBI Official Symbol: | VPS11 |
| NCBI Official Synonym Symbols: | END1; PEP5; HLD12; RNF108; hVPS11 |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 11 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 11 homolog |
| UniProt Synonym Protein Names: | RING finger protein 108 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS11 |
| UniProt Entry Name: | VPS11_HUMAN |
