Cell Biology Antibodies 17
Anti-Vitronectin Antibody (CAB4883)
- SKU:
- CAB4883
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- V75
- Synonyms:
- VN
- Synonyms:
- VNT
- Research Area:
- Cell Biology
Description
| Product Name: | Vitronectin Rabbit mAb |
| Product Code: | CAB4883 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | V75, VN, VNT |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Vitronectin |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HepG2 |
| Immunogen: | A synthesized peptide derived from human Vitronectin |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7448 |
| Uniprot: | P04004 |
| Cellular Location: | Secreted, extracellular space |
| Calculated MW: | 75kDa |
| Observed MW: | 75KDa |
| UniProt Protein Function: | VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 17q11 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region Molecular Function:heparin binding; integrin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding Biological Process: receptor-mediated endocytosis; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; negative regulation of blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of complement activation; cell adhesion mediated by integrin; innate immune response; immune response; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P04004 |
| NCBI GenInfo Identifier: | 139653 |
| NCBI Gene ID: | 7448 |
| NCBI Accession: | P04004.1 |
| UniProt Related Accession: | P04004 |
| Molecular Weight: | |
| NCBI Full Name: | Vitronectin |
| NCBI Synonym Full Names: | vitronectin |
| NCBI Official Symbol: | VTN |
| NCBI Official Synonym Symbols: | VN; V75; VNT |
| NCBI Protein Information: | vitronectin |
| UniProt Protein Name: | Vitronectin |
| UniProt Synonym Protein Names: | S-protein; Serum-spreading factor; V75Cleaved into the following 3 chains:Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B |
| Protein Family: | Vitronectin |
| UniProt Gene Name: | VTN |
| UniProt Entry Name: | VTNC_HUMAN |
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