Cell Biology Antibodies 7

Anti-VIP Antibody (CAB1804)

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SKU:
CAB1804
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-VIP Antibody
Antibody SKU:CAB1804
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-170 of human VIP (NP_003372.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, U-87MG, SH-SY5Y, Mouse spleen, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 31-170 of human VIP (NP_003372.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:APSA LRLG DRIP FEGA NEPD QVSL KEDI DMLQ NALA ENDT PYYD VSRN ARHA DGVF TSDF SKLL GQLS AKKY LESL MGKR VSSN ISED PVPV KRHS DAVF TDNY TRLR KQMA VKKY LNSI LNGK RSSE GESP DFPE ELEK
Gene ID:7432
Uniprot:P01282
Cellular Location:Secreted
Calculated MW:19kDa
Observed MW:14kDa
Synonyms:VIP, PHM27
Background:The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
UniProt Protein Function:VIP: VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q25.2

Cellular Component: extracellular region

Molecular Function:hormone activity; neuropeptide hormone activity; protein binding

Biological Process: body fluid secretion; G-protein coupled receptor protein signaling pathway; mRNA stabilization; positive regulation of cell proliferation; positive regulation of protein catabolic process; regulation of protein localization

NCBI Summary:The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
UniProt Code:P01282
NCBI GenInfo Identifier:138574
NCBI Gene ID:7432
NCBI Accession:P01282.1
UniProt Secondary Accession:P01282,Q5TCY8, Q5TCY9, Q96QK3,
UniProt Related Accession:P01282
Molecular Weight:
NCBI Full Name:VIP peptides
NCBI Synonym Full Names:vasoactive intestinal peptide
NCBI Official Symbol:VIP  
NCBI Official Synonym Symbols:PHM27  
NCBI Protein Information:VIP peptides
UniProt Protein Name:VIP peptides
UniProt Synonym Protein Names:Intestinal peptide PHV-42Alternative name(s):Peptide histidine valine 42
Protein Family:VIP peptides
UniProt Gene Name:VIP  
Anti-VIP Antibody (CAB1804)Western blot analysis of extracts of various cell lines, using VIP Antibody (CAB1804) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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