| Background: | This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR have been shown to function as modulators of Sec insertion in this protein (PMID:23614019). An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene. |
| UniProt Protein Function: | Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. |
| NCBI Summary: | This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017] |
| UniProt Code: | Q9BQE4 |
| NCBI GenInfo Identifier: | 33285002 |
| NCBI Gene ID: | 55829 |
| NCBI Accession: | NP_060915.2 |
| UniProt Secondary Accession: | Q9BQE4,Q3B771, Q9P0I6, |
| UniProt Related Accession: | Q9BQE4 |
| Molecular Weight: | Calculated: 21kDaObserved: 21kDa |
| NCBI Full Name: | selenoprotein S isoform 1 |
| NCBI Synonym Full Names: | selenoprotein S |
| NCBI Official Symbol: | SELENOS |
| NCBI Official Synonym Symbols: | SELS; VIMP; ADO15; SBBI8; SEPS1; AD-015 |
| NCBI Protein Information: | selenoprotein S |
| UniProt Protein Name: | Selenoprotein S |
| UniProt Synonym Protein Names: | VCP-interacting membrane protein |
| Protein Family: | Selenoprotein |
| UniProt Gene Name: | SELENOS |
