Signal Transduction Antibodies 1
Anti-VGF Antibody (CAB14795)
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- SKU:
- CAB14795
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-VGF Antibody |
| Antibody SKU: | CAB14795 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-615 of human VGF (NP_003369.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: | Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-615 of human VGF (NP_003369.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ADDV VSII EEVE EKRK RKKN APPE PVPP PRAA PAPT HVRS PQPP PPAP APAR DELP DWNE VLPP WDRE EDEV YPPG PYHP FPNY IRPR TLQP PSAL RRRH YHHA LPPS RHYP GREA QARR AQEE AEAE ERRL QEQE ELEN YIEH VLLR RP |
| Gene ID: | 7425 |
| Uniprot: | O15240 |
| Cellular Location: | Cytoplasmic vesicle, Secreted, secretory vesicle |
| Calculated MW: | 67kDa |
| Observed MW: | 70kDa |
| Synonyms: | VGF, SCG7, SgVII |
| Background: | This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. |
| UniProt Protein Function: | VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: extracellular space; transport vesicle; cytoplasmic vesicle Molecular Function:neuropeptide hormone activity; growth factor activity Biological Process: response to dietary excess; generation of precursor metabolites and energy; response to cAMP; ovarian follicle development; insulin secretion; sexual reproduction; defense response to bacterium; response to cold; glucose homeostasis; response to insulin stimulus |
| NCBI Summary: | This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15240 |
| NCBI GenInfo Identifier: | 206729943 |
| NCBI Gene ID: | 7425 |
| NCBI Accession: | O15240.2 |
| UniProt Secondary Accession: | O15240,Q9UDW8, |
| UniProt Related Accession: | O15240 |
| Molecular Weight: | 67,258 Da |
| NCBI Full Name: | Neurosecretory protein VGF |
| NCBI Synonym Full Names: | VGF nerve growth factor inducible |
| NCBI Official Symbol: | VGF |
| NCBI Protein Information: | neurosecretory protein VGF; neuro-endocrine specific protein VGF |
| UniProt Protein Name: | Neurosecretory protein VGF |
| Protein Family: | Neurosecretory protein |
| UniProt Gene Name: | VGF |
| UniProt Entry Name: | VGF_HUMAN |
 | Western blot analysis of extracts of rat brain, using VGF antibody (CAB14795) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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