Anti-Versican Antibody (CAB20278)
- SKU:
- CAB20278
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- WGN
- Synonyms:
- ERVR
- Synonyms:
- GHAP
- Synonyms:
- PG-M
- Synonyms:
- WGN1
- Synonyms:
- CSPG2
Description
| Product Name: | Versican Rabbit pAb |
| Product Code: | CAB20278 |
| Size: | 50uL, 100uL |
| Synonyms: | WGN, ERVR, GHAP, PG-M, WGN1, CSPG2 |
| Applications: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human Versican . |
| Applications: | IF |
| Recommended Dilutions: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human Versican . |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1462 |
| Uniprot: | P13611 |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | CSPG2: May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1). WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN. Belongs to the aggrecan/versican proteoglycan family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 5q14.3 Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; lysosomal lumen; intracellular membrane-bound organelle; membrane; Golgi lumen; extracellular region Molecular Function:protein binding; glycosaminoglycan binding; extracellular matrix structural constituent; hyaluronic acid binding; calcium ion binding; carbohydrate binding Biological Process: extracellular matrix organization and biogenesis; central nervous system development; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; multicellular organismal development; heart development; cell recognition; pathogenesis; glial cell migration; dermatan sulfate biosynthetic process; chondroitin sulfate metabolic process; osteoblast differentiation; chondroitin sulfate catabolic process; carbohydrate metabolic process; cell adhesion; skeletal development Disease: Wagner Vitreoretinopathy |
| NCBI Summary: | This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P13611 |
| NCBI GenInfo Identifier: | 21361116 |
| NCBI Gene ID: | 1462 |
| NCBI Accession: | NP_004376.2 |
| UniProt Secondary Accession: | P13611,P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5 |
| UniProt Related Accession: | P13611 |
| Molecular Weight: | 369,688 Da |
| NCBI Full Name: | versican core protein isoform 1 |
| NCBI Synonym Full Names: | versican |
| NCBI Official Symbol: | VCAN |
| NCBI Official Synonym Symbols: | WGN; ERVR; GHAP; PG-M; WGN1; CSPG2 |
| NCBI Protein Information: | versican core protein |
| UniProt Protein Name: | Versican core protein |
| UniProt Synonym Protein Names: | Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan 2; Glial hyaluronate-binding protein; GHAP; Large fibroblast proteoglycan; PG-M |
| UniProt Gene Name: | VCAN |
| UniProt Entry Name: | CSPG2_HUMAN |
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