Cell Biology Antibodies 8
Anti-VEGFB Antibody (CAB2132)
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- SKU:
- CAB2132
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-VEGFB Antibody |
| Antibody SKU: | CAB2132 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human VEGFB (NP_003368.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human VEGFB (NP_003368.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QILM IRYP SSQL GEMS LEEH SQCE CRPK KKDS AVKP DRAA TPHH RPQP RSVP GWDS APGA PSPA DITH PTPA PGPS AHAA PSTT SALT PGPA AAAA DAAA S |
| Gene ID: | 7423 |
| Uniprot: | P49765 |
| Cellular Location: | Secreted |
| Calculated MW: | 21kDa |
| Observed MW: | 32KDa |
| Synonyms: | VEGFB, VEGFL, VRF, VEGF-B |
| Background: | This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | VEGFB: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cell cycle regulation; Motility/polarity/chemotaxis; Cytokine Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular region Molecular Function:protein binding Biological Process: platelet degranulation; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P49765 |
| NCBI GenInfo Identifier: | 17380554 |
| NCBI Gene ID: | 7423 |
| NCBI Accession: | P49765.2 |
| UniProt Secondary Accession: | P49765,Q16528, |
| UniProt Related Accession: | P49765 |
| Molecular Weight: | 21,261 Da |
| NCBI Full Name: | Vascular endothelial growth factor B |
| NCBI Synonym Full Names: | vascular endothelial growth factor B |
| NCBI Official Symbol: | VEGFB |
| NCBI Official Synonym Symbols: | VRF; VEGFL |
| NCBI Protein Information: | vascular endothelial growth factor B |
| UniProt Protein Name: | Vascular endothelial growth factor B |
| UniProt Synonym Protein Names: | VEGF-related factor; VRF |
| Protein Family: | Vascular endothelial growth factor |
| UniProt Gene Name: | VEGFB |
| UniProt Entry Name: | VEGFB_HUMAN |
 | Western blot analysis of extracts of Rat heart, using VEGFB Rabbit pAb (CAB2132) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
 | Immunofluorescence analysis of C6 cells using VEGFB Rabbit pAb (CAB2132) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH-3T3 cells using VEGFB Rabbit pAb (CAB2132) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using VEGFB Rabbit pAb (CAB2132) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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