Cardiovascular Antibodies
Anti-VEGF Receptor 1 Antibody (CAB1277)
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- SKU:
- CAB1277
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Antibody Name: | Anti-VEGF Receptor 1 Antibody |
| Antibody SKU: | CAB1277 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human VEGF Receptor 1 (NP_001153392.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse kidney, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human VEGF Receptor 1 (NP_001153392.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTGS SSGS KLKD PELS LKGT QHIM QAGQ TLHL QCRG EAAH KWSL PEMV SKES ERLS ITKS ACGR NGKQ FCST LTLN TAQA NHTG FYSC KYLA VPTS KKKE TESA IYIF ISDT GRPF VEMY SEIP EIIH MTEG RELV IPCR VTSP NITV TLKK FPLD TLIP DGKR IIWD SRKG FIIS NATY KEIG LLTC EATV NGHL YKTN YLTH RQTN TIID VQIS TPRP VKLL RGHT LVLN CTAT TPLN TRVQ MTWS YPDE KNKR ASVR RRID QSNS HANI FYSV LTID K |
| Gene ID: | 2321 |
| Uniprot: | P17948 |
| Cellular Location: | Cell membrane, Cytoplasm, Endosome, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 39kDa/41kDa/52- 82kDa/150kDa |
| Observed MW: | 151kDa |
| Synonyms: | FLT, FLT-1, VEGFR-1, VEGFR1, FLT1 |
| Background: | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia. |
| UniProt Protein Function: | VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; Membrane protein, integral; TK group; VEGFR family Chromosomal Location of Human Ortholog: 13q12 Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome Molecular Function:identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; embryonic morphogenesis; sprouting angiogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration |
| NCBI Summary: | This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009] |
| UniProt Code: | P17948 |
| NCBI GenInfo Identifier: | 143811474 |
| NCBI Gene ID: | 2321 |
| NCBI Accession: | P17948.2 |
| UniProt Secondary Accession: | P17948,O60722, A3E342, A3E344, A8KA71, B0LPF1, B2BF46 B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, |
| UniProt Related Accession: | P17948 |
| Molecular Weight: | 41,175 Da |
| NCBI Full Name: | Vascular endothelial growth factor receptor 1 |
| NCBI Synonym Full Names: | fms-related tyrosine kinase 1 |
| NCBI Official Symbol: | FLT1 |
| NCBI Official Synonym Symbols: | FLT; FLT-1; VEGFR1; VEGFR-1 |
| NCBI Protein Information: | vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) |
| UniProt Protein Name: | Vascular endothelial growth factor receptor 1 |
| UniProt Synonym Protein Names: | Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor |
| Protein Family: | Vascular endothelial growth factor receptor |
| UniProt Gene Name: | FLT1 |
| UniProt Entry Name: | VGFR1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VEGF Receptor 1 antibody (CAB1277) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat spleen using FLT1 antibody (CAB1277) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human placenta using FLT1 antibody (CAB1277) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using FLT1 antibody (CAB1277) at dilution of 1:100 (40x lens). |
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