Cell Cycle Antibodies 1
Anti-VASH1 Antibody (CAB6148)
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- SKU:
- CAB6148
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-VASH1 Antibody |
| Antibody SKU: | CAB6148 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | THP-1, Mouse brain, Mouse stomach |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPGG KKVA GGGS SGAT PTSA AATA PSGV RRLE TSEG TSAQ RDEE PEEE GEED LRDG GVPF FVNR GGLP VDEA TWER MWKH VAKI HPDG EKVA QRIR GATD LPKI PIPS VPTF QPST PVPE RLEA VQRY IREL QYNH TGTQ FFEI KKSR PLTG LMDL AKEM TKEA LPIK CLEA VILG IYLT NSMP TLER FPIS FKTY FSGN YFRH IVLG VNFA GRYG ALGM SRRE DLMY KPPA FRTL SELV LDFE AAYG RCWH VLKK VKLG QSVS HDPH SVEQ IEWK HSVL DVER LGRD DFRK ELER HARD MRLK IGKG TGPP SPTK DRKK DVSS PQRA QSSP HRRN SRSE RRPS GDKK TSEP KAMP DLNG YQIR V |
| Gene ID: | 22846 |
| Uniprot: | Q7L8A9 |
| Cellular Location: | Secreted |
| Calculated MW: | 21kDa/40kDa |
| Observed MW: | 41kDa |
| Synonyms: | VASH1, KIAA1036 |
| Background: |
| UniProt Protein Function: | VASH1: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Belongs to the vasohibin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: extracellular space; apical part of cell; endoplasmic reticulum; cytoplasm Biological Process: negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to wounding; angiogenesis; cell cycle arrest; negative regulation of blood vessel endothelial cell migration |
| UniProt Code: | Q7L8A9 |
| NCBI GenInfo Identifier: | 62511163 |
| NCBI Gene ID: | 22846 |
| NCBI Accession: | Q7L8A9.1 |
| UniProt Secondary Accession: | Q7L8A9,Q96H02, Q9UBF4, Q9Y629, |
| UniProt Related Accession: | Q7L8A9 |
| Molecular Weight: | 365 |
| NCBI Full Name: | Vasohibin-1 |
| NCBI Synonym Full Names: | vasohibin 1 |
| NCBI Official Symbol: | VASH1 |
| NCBI Official Synonym Symbols: | KIAA1036 |
| NCBI Protein Information: | vasohibin-1 |
| UniProt Protein Name: | Vasohibin-1 |
| Protein Family: | Vasohibin |
| UniProt Gene Name: | VASH1 |
| UniProt Entry Name: | VASH1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VASH1 antibody (CAB6148) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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