Cell Cycle Antibodies 1

Anti-VASH1 Antibody (CAB12569)

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SKU:
CAB12569
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Cycle

Description

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Antibody Name:Anti-VASH1 Antibody
Antibody SKU:CAB12569
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse brain, Mouse stomach
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-365 of human VASH1 (NP_055724.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPGG KKVA GGGS SGAT PTSA AATA PSGV RRLE TSEG TSAQ RDEE PEEE GEED LRDG GVPF FVNR GGLP VDEA TWER MWKH VAKI HPDG EKVA QRIR GATD LPKI PIPS VPTF QPST PVPE RLEA VQRY IREL QYNH TGTQ FFEI KKSR PLTG LMDL AKEM TKEA LPIK CLEA VILG IYLT NSMP TLER FPIS FKTY FSGN YFRH IVLG VNFA GRYG ALGM SRRE DLMY KPPA FRTL SELV LDFE AAYG RCWH VLKK VKLG QSVS HDPH SVEQ IEWK HSVL DVER LGRD DFRK ELER HARD MRLK IGKG TGPP SPTK DRKK DVSS PQRA QSSP HRRN SRSE RRPS GDKK TSEP KAMP DLNG YQIR V
Gene ID:22846
Uniprot:Q7L8A9
Cellular Location:Secreted
Calculated MW:21kDa/40kDa
Observed MW:41kDa
Synonyms:VASH1, KIAA1036
Background:
UniProt Protein Function:VASH1: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Belongs to the vasohibin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; apical part of cell; endoplasmic reticulum; cytoplasm

Biological Process: negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to wounding; angiogenesis; cell cycle arrest; negative regulation of blood vessel endothelial cell migration

UniProt Code:Q7L8A9
NCBI GenInfo Identifier:62511163
NCBI Gene ID:22846
NCBI Accession:Q7L8A9.1
UniProt Secondary Accession:Q7L8A9,Q96H02, Q9UBF4, Q9Y629,
UniProt Related Accession:Q7L8A9
Molecular Weight:365
NCBI Full Name:Vasohibin-1
NCBI Synonym Full Names:vasohibin 1
NCBI Official Symbol:VASH1  
NCBI Official Synonym Symbols:KIAA1036  
NCBI Protein Information:vasohibin-1
UniProt Protein Name:Vasohibin-1
Protein Family:Vasohibin
UniProt Gene Name:VASH1  
UniProt Entry Name:VASH1_HUMAN
Anti-VASH1 Antibody (CAB12569)Western blot analysis of extracts of various cell lines, using VASH1 antibody (CAB12569) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-VASH1 Antibody (CAB12569)Immunohistochemistry of paraffin-embedded human prostate cancer using VASH1 antibody (CAB12569) at dilution of 1:100 (40x lens).
Anti-VASH1 Antibody (CAB12569)Immunohistochemistry of paraffin-embedded human esophageal cancer using VASH1 antibody (CAB12569) at dilution of 1:100 (20x lens).
Anti-VASH1 Antibody (CAB12569)Immunohistochemistry of paraffin-embedded mouse brain using VASH1 antibody (CAB12569) at dilution of 1:100 (40x lens).
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