Cell Biology Antibodies 11

Anti-VANGL2 Antibody (CAB7825)

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SKU:
CAB7825
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-VANGL2 Antibody
Antibody SKU:CAB7825
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human VANGL2 (NP_065068.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, A-549, Mouse brain, Mouse spinal cord, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human VANGL2 (NP_065068.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDTE SQYS GYSY KSGH SRSS RKHR DRRD RHRS KSRD GGRG DKSV TIQA PGEP LLDN ESTR GDER DDNW GETT TVVT GTSE HSIS HDDL TRIA KDME DSVP LDCS RHLG VA
Gene ID:57216
Uniprot:Q9ULK5
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:59kDa
Observed MW:70kDa
Synonyms:VANGL2, LPP1, LTAP, STB1, STBM, STBM1
Background:The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.
UniProt Protein Function:VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis

Disease: Neural Tube Defects

NCBI Summary:The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
UniProt Code:Q9ULK5
NCBI GenInfo Identifier:38258849
NCBI Gene ID:57216
NCBI Accession:Q9ULK5.2
UniProt Secondary Accession:Q9ULK5,Q5T212, D3DVE9,
UniProt Related Accession:Q9ULK5
Molecular Weight:59,714 Da
NCBI Full Name:Vang-like protein 2
NCBI Synonym Full Names:VANGL planar cell polarity protein 2
NCBI Official Symbol:VANGL2  
NCBI Official Synonym Symbols:LPP1; LTAP; STB1; STBM; STBM1  
NCBI Protein Information:vang-like protein 2
UniProt Protein Name:Vang-like protein 2
UniProt Synonym Protein Names:Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family:Vang-like protein
UniProt Gene Name:VANGL2  
UniProt Entry Name:VANG2_HUMAN
Anti-VANGL2 Antibody (CAB7825)Western blot analysis of extracts of various cell lines, using VANGL2 antibody (CAB7825) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-VANGL2 Antibody (CAB7825)Immunohistochemistry of paraffin-embedded human kidney cancer using VANGL2 antibody (CAB7825) at dilution of 1:100 (40x lens).
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